Inhibition of quorum sensing and biofilm formation in Vibrio harveyi by 4-fluoro-DPD; a novel potent inhibitor of Al-2 signalling

被引：27

作者：

Kadirvel, Manikandan ^{[1
,2
]}

Fanimarvasti, Fariba ^{[1
]}

Forbes, Sarah ^{[1
]}

McBain, Andrew ^{[1
]}

Gardiner, John M. ^{[3
]}

Brown, Gavin D. ^{[2
]}

Freeman, Sally ^{[1
]}

机构：

[1] Univ Manchester, Manchester Pharm Sch, Manchester M13 9PT, Lancs, England

[2] Univ Manchester, Wolfson Mol Imaging Ctr, Manchester M20 3LJ, Lancs, England

[3] Univ Manchester, MIB, Sch Chem, Manchester M1 7DN, Lancs, England

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 39期

关键词：

ESCHERICHIA-COLI; BORON BINDING; RECALCITRANCE; INFECTION; MOLECULE; ANALOGS;

D O I：

10.1039/c3cc49678c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(S)-4,5-Dihydroxypentane-2,3-dione [(S)-DPD, (1)] is a precursor for Al-2, a quorum sensing signalling molecule for inter-and intra-species bacterial communication. The synthesis of its fluoro-analogue, 4-fluoro-5-hydroxypentane-2,3-dione (2) is reported. An intermediate in this route also enables a new, shorter synthesis of the native (S)-DPD. 4-Fluoro-DPD (2) completely inhibited bioluminescence and bacterial growth of Vibrio harveyi BB170 strain at 12.5 mu M and 100 mu M, respectively.

引用

页码：5000 / 5002

页数：3

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