A facile synthesis of the novel thiazolo[3,2-a]pyrimidine derivatives

被引：16
|
作者：
Studzinska, Renata [1 ]
Wroblewski, Marcin [1 ]
Karczmarska-Wodzka, Aleksandra [1 ]
Kolodziejska, Renata [1 ]
机构：
[1] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Gen Chem, PL-85626 Bydgoszcz, Poland
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 07期
关键词：
Thiazolo[3,2-a]pyrimidine derivatives; 2-Halomethylthiazolo[3,2-a]pyrimidine derivatives; Organic synthesis; Thiazole ring closure; Substitution reaction; Elimination reaction; RITANSERIN;
D O I：
10.1016/j.tetlet.2014.01.033
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-Bromomethyl- and 2-iodomethyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-5-ones are prepared via the reaction of 3-allyl-2-thiouracil derivatives with bromine or iodine chloride, respectively. The 6-bromo and 6-nitro derivatives are synthesized by an electrophilic substitution at C-6 of the thiazolopyrimidine system. As a result, novel 2,3-dihydrothiazolo[3,2-a]pyrimidin-5-one derivatives are obtained. Hydrogen halide elimination from the 2-halomethy1-2,3-dihydrothiazolo[3,2-a]pyrimidin-5-ones is also reported. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1384 / 1386
页数：3
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