A facile synthesis of the novel thiazolo[3,2-a]pyrimidine derivatives

被引：16

作者：

Studzinska, Renata ^{[1
]}

Wroblewski, Marcin ^{[1
]}

Karczmarska-Wodzka, Aleksandra ^{[1
]}

Kolodziejska, Renata ^{[1
]}

机构：

[1] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Gen Chem, PL-85626 Bydgoszcz, Poland

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 07期

关键词：

Thiazolo[3,2-a]pyrimidine derivatives; 2-Halomethylthiazolo[3,2-a]pyrimidine derivatives; Organic synthesis; Thiazole ring closure; Substitution reaction; Elimination reaction; RITANSERIN;

D O I：

10.1016/j.tetlet.2014.01.033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Bromomethyl- and 2-iodomethyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-5-ones are prepared via the reaction of 3-allyl-2-thiouracil derivatives with bromine or iodine chloride, respectively. The 6-bromo and 6-nitro derivatives are synthesized by an electrophilic substitution at C-6 of the thiazolopyrimidine system. As a result, novel 2,3-dihydrothiazolo[3,2-a]pyrimidin-5-one derivatives are obtained. Hydrogen halide elimination from the 2-halomethy1-2,3-dihydrothiazolo[3,2-a]pyrimidin-5-ones is also reported. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1384 / 1386

页数：3

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