Enzymatic degradation of block copolymers prepared from ε-caprolactone and poly(ethylene glycol)

被引:127
作者
Li, SM [1 ]
Garreau, H [1 ]
Pauvert, B [1 ]
McGrath, J [1 ]
Toniolo, A [1 ]
Vert, M [1 ]
机构
[1] Fac Pharm Montpellier, Ctr Rech Biopolymeres Artificiels, F-34060 Montpellier 2, France
关键词
D O I
10.1021/bm010168s
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Block copolymers were prepared by ring-opening polymerization of E-caprolactone in the presence of monohydroxyl or dihydroxyl poly(ethylene glycol) (PEG). using Zn powder as catalyst. The resulting poly(c-caprolactone) (PCL)-PEG diblock and PCL-PEG-PCL triblock copolymers were characterized by various analytical techniques such as NMR, size-exclusion chromatography, differential scanning calorimetry, and X-ray diffraction. Both copolymers were semicrystalline polymers, the crystalline structure being of the PCL type. Films were prepared by casting dichloromethane solutions of the polymers on a glass plate. Square samples with dimensions of 10 x 10 mm were allowed to degrade in a pH = 7.0 phosphate buffer solution containing Pseudomonas lipase. Data showed that the introduction of PEG blocks did not decrease the degradation rate of poly (epsilon-caprolactone).
引用
收藏
页码:525 / 530
页数:6
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