Hypofolins A - L, ent-Labdane Diterpenoids from the Roots of Hypoestes phyllostachya "Pink Splash'

被引：8

作者：

Cheng, Bin ^{[1
,2
,3
]}

Ding, Lin-Fen ^{[2
,3
]}

Yan, Tong ^{[1
,2
,3
]}

Xie, Zhang-Qiao ^{[1
,2
,3
]}

Zhang, Zhi-jun ^{[1
]}

Song, Liu-Dong ^{[2
,3
]}

Wu, Xing-De ^{[1
]}

Zhao, Qin-Shi ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[2] Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China

[3] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2018年 / 15卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Hypoestes phyllostachya; ent-labdane diterpenoids; hypofolins A - L; cytotoxicity; NO production inhibitory activity; ACANTHACEAE; SERPENS; FORSKALEI; ROSEA;

D O I：

10.1002/cbdv.201800124

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twelve new ent-labdane diterpenoids, hypofolins A - F (1 - 6) and hypofolins G - L (7a/7b, 8a/8b, and 9a/9b), were isolated from the roots of Hypoestes phyllostachya Pink Splash'. Their structures were elucidated by extensive 1D- and 2D-NMR spectroscopic and HR-MS data. The absolute configurations of 1, 2, 5, and 7a/7b were determined by single crystal X-ray diffraction and ECD analysis, as well as chemical transformations. Compounds 7a/7b, 8a/8b, and 9a/9b were isolated as three pairs of interconverting mixture of two isomers between ketone and hemiketal types. Compound 1 showed weak cytotoxicity against SMMC-7721 cell line with IC50 value of 31.40 m.

引用

页数：12

共 18 条

[1] ROSEATOXIDE AND DIHYPOESTOXIDE - ADDITIONAL NEW DITERPENOIDS FROM HYPOESTES-ROSEA [J].