Prediction of all-cause mortality with hypoalbuminemia in patients with heart failure: a meta-analysis

被引:30
作者
Peng, Wenhua [1 ]
Zhang, Channa [2 ]
Wang, Zhijun [3 ]
Yang, Wenqi [3 ]
机构
[1] China Japan Friendship Hosp, Dept Cardiol, 2 Yinghuayuan East St, Beijing 100029, Peoples R China
[2] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing, Peoples R China
[3] North China Univ Sci & Technol, Affiliated Hosp, Cardiol Dept 2, Tangshan, Hebei, Peoples R China
关键词
Heart failure; hypoalbuminemia; all-cause mortality; meta-analysis; HUMAN SERUM-ALBUMIN; PROGNOSTIC-SIGNIFICANCE; HOSPITAL MORTALITY; IMPACT; DEATH; RISK;
D O I
10.1080/1354750X.2019.1652686
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Objective: The prognostic utility of serum albumin level for mortality in heart failure patients has received considerable attention. This meta-analysis sought to examine the prognostic significance of hypoalbuminemia for prediction of all-cause mortality in patients with heart failure. Materials and methods: Pubmed and Embase databases were systematically searched up to 10 March 2019 to identify eligible studies. Epidemiological studies reporting a multivariable-adjusted risk estimate of all-cause mortality associated with hypoalbuminemia in acute or chronic heart failure patients were included. Results: Nine studies from 10 articles involving 16,763 heart failure patients were included in the final analysis. Hypoalbuminemia was associated with an increased in-hospital mortality (risk ratio [RR] 4.90; 95% confidence interval [CI] 2.96-8.10) and long-term all-cause mortality (RR 1.75; 95% CI 1.35-2.27) in acute heart failure patients. Chronic heart failure patients with hypoalbuminemia exhibited a 3.5-fold (95% CI 1.29-9.73) higher risk for long-term all-cause mortality. Conclusions: Hypoalbuminemia is possibly an independent predictor of all-cause mortality in patients with acute or chronic heart failure. However, the current findings should be further confirmed in future prospective studies. Moreover, future well-designed randomized controlled trials would be required to investigate whether correcting hypoalbuminemia in heart failure patients has potential to improve survival outcome.
引用
收藏
页码:631 / 637
页数:7
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