Isovitexin alleviates liver injury induced by lipopolysaccharide/D-galactosamine by activating Nrf2 and inhibiting NF-κB activation

被引：34
作者：
Hu, Jian-Jian [1 ,2 ]
Wang, Hui [3 ]
Pan, Chen-Wei [2 ,4 ]
Lin, Meng-Xiang [1 ,2 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol Crit Care & Pain Med, Wenzhou 325027, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China
[3] Kunming Med Univ, Affiliated YanAn Hosp, Dept Gastroenterol, Kunming 650051, Yunnan, Peoples R China
[4] Wenzhou Med Univ, Affiliated Hosp 2, Dept Infect Dis, Wenzhou 325027, Peoples R China
来源：
MICROBIAL PATHOGENESIS | 2018年 / 119卷
关键词：
Lipopolysaccharide; Acute liver injury; Isovitexin; TNF-alpha; OXIDATIVE STRESS; INDUCED APOPTOSIS; HEPATIC-FAILURE; MECHANISMS; MICE; PATHOGENESIS; INVOLVEMENT; ENDOTOXIN; TOXICITY; PATHWAYS;
D O I：
10.1016/j.micpath.2018.03.053
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The aim of this study was to investigate the protective effects and mechanism of isovitexin, a glycosylflavonoid isolated from rice hulls of Oryza sativa, on Lipopolysaccharide (LPS)/D-galactosamine (D-Gal)-induced acute liver injury. The mice were randomly divided into five groups: control group, LPS/D-Gal group, and LPS/D-Gal + isovitexin groups. The mice of LPS/D-Gal group were received of LPS (50 mu g/kg) and D-gal (800 mg/kg) intraperitoneal. The mice of LPS/D-Gal + isovitexin groups were received isovitexin (25, 50, 100 mg/kg) 1 h before LPS/D-Gal treatment. The results showed that the severity of liver injury was attenuated by treatment of isovitexin, as confirmed by the decreased liver histopathologic changes, as well as serum AST and ALT levels. Furthermore, the levels of TNF-alpha in serum and liver tissues, MPO activity and MDA content were significantly inhibited by isovitexin. In addition, isovitexin significantly attenuated NF-kappa B phosphorylation induced by LPS/ D-Gal. The expression of Nrf2 and HO-1 were significantly up-regulated by isovitexin. In conclusion, isovitexin could protect against LPS/D-Gal-induced liver injury by inhibiting inflammatory and oxidative responses. Isovitexin also had protective effects against carbon tetrachloride (CCl4)-induced liver injury. Isovitexin may used as a potential agent for the treatment of liver injury.
引用
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页码：86 / 92
页数：7
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