Multitask learning and benchmarking with clinical time series data

被引:456
作者
Harutyunyan, Hrayr [1 ]
Khachatrian, Hrant [2 ,3 ]
Kale, David C. [1 ]
Ver Steeg, Greg [1 ]
Galstyan, Aram [1 ]
机构
[1] USC Informat Sci Inst, Marina Del Rey, CA 90292 USA
[2] YerevaNN, Yerevan 0025, Armenia
[3] Yerevan State Univ, Yerevan 0025, Armenia
关键词
INTENSIVE-CARE-UNIT; EARLY WARNING SCORE; LENGTH-OF-STAY; ARTIFICIAL NEURAL-NETWORK; IN-HOSPITAL MORTALITY; ACUTE PHYSIOLOGY; HIGH-COST; ICU; SEVERITY; ILLNESS;
D O I
10.1038/s41597-019-0103-9
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Health care is one of the most exciting frontiers in data mining and machine learning. Successful adoption of electronic health records (EHRs) created an explosion in digital clinical data available for analysis, but progress in machine learning for healthcare research has been difficult to measure because of the absence of publicly available benchmark data sets. To address this problem, we propose four clinical prediction benchmarks using data derived from the publicly available Medical Information Mart for Intensive Care (MIMIC-III) database. These tasks cover a range of clinical problems including modeling risk of mortality, forecasting length of stay, detecting physiologic decline, and phenotype classification. We propose strong linear and neural baselines for all four tasks and evaluate the effect of deep supervision, multitask training and data-specific architectural modifications on the performance of neural models.
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页数:18
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