Product Fermented by Lactobacilli Induces Changes in Intracellular Calcium Dynamics in Rat Brain Neurons

被引：0

作者：

Sobol, C. V. ^{[1
]}

Belostotskaya, G. B. ^{[1
]}

机构：

[1] Russian Acad Sci, IM Sechenov Evolutionary Physiol & Biochem Inst, St Petersburg 194223, Russia

来源：

BIOLOGICHESKIE MEMBRANY | 2015年 / 32卷 / 5-6期

关键词：

calcium; neurons; microflora; intracelluar signaling; gastrointestinal tract; brain; brain-gut axis; metabolome; probiotics; lactobacteria; microbiome; PROTEIN-KINASE-C; ALZHEIMERS-DISEASE; INTESTINAL MICROBIOTA; NEUROTROPHIC FACTOR; VAGAL PATHWAYS; PRESENILINS; EXPRESSION; PROMOTES; BEHAVIOR;

D O I：

10.7868/S023347551505014X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this paper we investigated the effect of concentrated metabolic products of lactobacilli (PP) on the dynamics of intracellular calcium in rat brain neurons. [Ca2+](i) was recorded using a fluorescent probe Fura-2 and a computer system for analysis of intracellular ions. It was found that PP increased [Ca2+](i), thus stimulating the intracellular signaling mechanisms. In these processes the activation of ryanodine receptors and protein kinase C are involved at least partially. Continuous application of PP stimulated a sustained release of Ca2+ from the endoplasmic reticulum and subsequent entry of Ca2+ into the cell. Given that PP is able to stimulate circulation and neurogenesis and is involved in calcium homeostasis in nerve cells, PP can be regarded as a product for the improvement of psychological parameters and cognitive functions of the brain.

引用

页码：399 / 408

页数：10

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