T Lymphocyte and CAR-T Cell-Derived Extracellular Vesicles and Their Applications in Cancer Therapy

被引:31
|
作者
Calvo, Victor [1 ]
Izquierdo, Manuel [2 ]
机构
[1] Univ Autonoma Madrid, Fac Med, Dept Bioquim, Inst Invest Biomed Alberto Sols CSIC UAM, Madrid 28029, Spain
[2] CSIC UAM, Inst Invest Biomed Alberto Sols, Dept Metab & Senalizac Celular, Madrid 28029, Spain
关键词
exosomes; T lymphocytes; immune synapse; secretory granules; multivesicular bodies; cytotoxic activity; cell death; CAR T lymphocytes; DIACYLGLYCEROL-KINASE-ALPHA; MICROTUBULE-ORGANIZING CENTER; BEARING FAS LIGAND; MULTIVESICULAR BODIES; EXOSOMES BEARING; LYTIC GRANULES; CENTROSOME POLARIZATION; RETICULOCYTE MATURATION; MOLECULAR-MECHANISMS; SECRETORY GRANULES;
D O I
10.3390/cells11050790
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Extracellular vesicles (EV) are a very diverse group of cell-derived vesicles released by almost all kind of living cells. EV are involved in intercellular exchange, both nearby and systemically, since they induce signals and transmit their cargo (proteins, lipids, miRNAs) to other cells, which subsequently trigger a wide variety of biological responses in the target cells. However, cell surface receptor-induced EV release is limited to cells from the immune system, including T lymphocytes. T cell receptor activation of T lymphocytes induces secretion of EV containing T cell receptors for antigen and several bioactive molecules, including proapoptotic proteins. These EV are specific for antigen-bearing cells, which make them ideal candidates for a cell-free, EV-dependent cancer therapy. In this review we examine the generation of EV by T lymphocytes and CAR-T cells and some potential therapeutic approaches of these EV.
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页数:27
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