Cushing's syndrome with a large pituitary adenoma producing both corticotropin-releasing hormone (CRH) and adrenocorticotropin (ACTH)

被引：5

作者：

Yamada, Y ^{[1
]}

Ohashi, A ^{[1
]}

Inoue, T ^{[1
]}

Sakaguchi, K ^{[1
]}

Tsujimura, T ^{[1
]}

Okamoto, D ^{[1
]}

Itatani, H ^{[1
]}

Fujimoto, N ^{[1
]}

Kusaka, K ^{[1
]}

Fushimi, H ^{[1
]}

机构：

[1] Sumitomo Hosp, Dept Internal Med, Kita Ku, Osaka 5300005, Japan

来源：

INTERNAL MEDICINE | 2002年 / 41卷 / 07期

关键词：

cortisol; dexamethasone suppression test; ectopic hormone-producing tumor;

D O I：

10.2169/internalmedicine.41.549

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 57-year-old man showed high serum cortisol, plasma adrenocorticotropin (ACTH) and corticotropin-releasing hormone (CRH) levels with a large pituitary tumor and a prostatic cancer. High dose dexamethasone did not suppress cortisol secretion and CRH administration did not stimulate cortisol secretion. After surgical removal of the pituitary tumor, plasma CRH, ACTH and serum cortisol levels were normalized. Histological examinations showed pituitary adenoma and prostatic adenocarcinoma, and pituitary adenoma was stained with both anti-CRH and anti-ACTH antibodies, but prostatic cancer was not stained. A CRH-producing pituitary adenoma is a new type of Cushing's syndrome.

引用

页码：549 / 554

页数：6

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