Platelet Rich Plasma in Orthopedic Surgical Medicine.

被引:88
作者
Everts, Peter A. [1 ]
van Erp, Albert [2 ]
DeSimone, Alfred [3 ]
Cohen, Dan S. [4 ]
Gardner, Ronald D. [5 ]
机构
[1] Gulf Coast Biol, Sci & Res Dept, Ft Myers, FL 33916 USA
[2] Orthoped Partnership, Son, Netherlands
[3] Orthoped Sports Med Ctr, Weston, FL USA
[4] Mt Sinai Med Ctr, Spine Care Inst Miami Beach, Miami Beach, FL 33140 USA
[5] Gardner Orthoped, Ft Myers, FL USA
关键词
Angiogenesis; antimicrobial; bioformulation; bone repair; leukocyte poor; leukocyte rich; O; orthopedic surgery; painkilling; platelet dose; platelet-rich plasma; spinal bone-fusion; tendon reconstruction;
D O I
10.1080/09537104.2020.1869717
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
There is a global interest in optimizing post-surgical tissue repair strategies, leading to better patient outcomes and fewer complications, most ideally with reduced overall cost. In this regard, in recent years, the interest in autologous biological treatments in orthopedic surgery and sports medicine has increased greatly, and the addition of platelet-rich plasma (PRP) to the surgical armamentarium is of particular note. Unfortunately, the number of PRP preparation devices has also grown immensely over the recent decades, raising meaningful concern for the considerable variation in the qualities of currently available PRP preparations. The lack of consensus on the standardization of PRP preparation and of agreement on condition specific PRP formulations is largely responsible for the sometimes contradictory outcomes in the literature. Furthermore, the full potential of PRP technology, the concept of individualized treatment protocols based on bioformulation options, and platelet dosing, angiogenesis, and antimicrobial and painkilling effects of PRP relevant to orthopedic surgery have rarely been addressed. In this review, we will discuss recent developments regarding PRP preparations and potential therapeutic effects. Additionally, we present a synopsis of several published data regarding PRP applications in orthopedic surgery for treating tendon injuries, inducing bone repair, strengthening spinal fusion outcomes, and supporting major joint replacements.
引用
收藏
页码:163 / 174
页数:12
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