The deformation of an adherent leukocyte under steady shear flow: a numerical study

被引:16
作者
Liu, XH
Wang, X
机构
[1] UHP, INPL, CNRS,UMR 7563, LEMTA, F-54500 Vandoeuvre Les Nancy, France
[2] Sichuan Univ, W China Med Ctr, Inst Biomed Engn, Chengdu 610041, Peoples R China
基金
中国国家自然科学基金;
关键词
leukocyte; deformation; numerical simulation; shear flow; adhesion;
D O I
10.1016/j.jbiomech.2003.11.015
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Leukocyte adhesion is a pathophysiological process in which the balance between hemodynamic and adhesion forces (molecular bonds) plays a key role. In this work, we studied the deformation of an adherent leukocyte and calculated the forces exerted on it. Three model cells were proposed, considering the leukocyte as a single drop, a compound drop, and a nucleus drop, representing a cell without nucleus, a cell with a nucleus, and a nucleus only, respectively. These model cells were supposedly adherent to a smooth substrate under steady shear flow. Our numerical results showed that all three model cells deformed in function of the initial contact angle, capillary number, and Reynolds number. The single drop was the most deformable, while the nucleus drop was the most resistant to the external flow. Each of the model cells showed maximum cell deformation at a high Reynolds number. The distribution of pressure on the cell confirmed the existence of a high-pressure region downstream of the drop, which retarded further deformation of the cell and provided a positive lift force on the drop. The consideration of a highly viscous nucleus can correct the over evaluation of the cell deformation in a flow. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1079 / 1085
页数:7
相关论文
共 50 条
[41]   Steady interaction of a vortex street with a shear flow [J].
Crowdy, Darren ;
Nelson, Rhodri .
PHYSICS OF FLUIDS, 2010, 22 (09)
[42]   Study of the motion of a spheroidal drop in a linear shear flow [J].
Armandoost, Parisa ;
Bayareh, Morteza ;
Nadooshan, Afshin Ahmadi .
JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY, 2018, 32 (05) :2059-2067
[43]   Numerical study of the phase separation in binary lipid membrane containing protein inclusions under stationary shear flow [J].
Chen, Xiao-Bo ;
Shi, Hui-Ji ;
Niu, Li-Sha .
JOURNAL OF BIOMECHANICS, 2009, 42 (05) :603-613
[44]   Statistics of polymer adsorption under shear flow [J].
He, Gui-Li ;
Messina, Rene ;
Loewen, Hartmut .
JOURNAL OF CHEMICAL PHYSICS, 2010, 132 (12)
[45]   Numerical study of viscosity and inertial effects on tank-treading and tumbling motions of vesicles under shear flow [J].
Kim, Yongsam ;
Lai, Ming-Chih .
PHYSICAL REVIEW E, 2012, 86 (06)
[46]   Numerical simulation in steady flow of Newtonian and shear thickening fluids in pipes with circular cross-section [J].
Galindo-Rosales, F. J. ;
Rubio-Hernandez, F. J. .
XVTH INTERNATIONAL CONGRESS ON RHEOLOGY - THE SOCIETY OF RHEOLOGY 80TH ANNUAL MEETING, PTS 1 AND 2, 2008, 1027 :1468-+
[47]   Deformation of a ferrofluid droplet in a simple shear flow under the effect of a constant magnetic field [J].
Capobianchi, Paolo ;
Lappa, Marcello ;
Oliveira, Monica S. N. .
COMPUTERS & FLUIDS, 2018, 173 :313-323
[48]   Mechanical properties of living adherent cells: Interaction of cell and shear flow [J].
Liu, Xiaoheng ;
Yu, Chang ;
Zou, Minjun ;
Yin, Hongmei .
BIOCERAMICS, VOL 19, PTS 1 AND 2, 2007, 330-332 :1169-+
[49]   Experimental and Numerical Investigation of Local Scour for Suspended Square Caisson under Steady Flow [J].
Qiqi Xiang ;
Kai Wei ;
Yadong Li ;
Mingjin Zhang ;
Shunquan Qin .
KSCE Journal of Civil Engineering, 2020, 24 :2682-2693
[50]   Experimental and Numerical Investigation of Local Scour for Suspended Square Caisson under Steady Flow [J].
Xiang, Qiqi ;
Wei, Kai ;
Li, Yadong ;
Zhang, Mingjin ;
Qin, Shunquan .
KSCE JOURNAL OF CIVIL ENGINEERING, 2020, 24 (09) :2682-2693