Development of a Rapid LC-MS-MS Method for Multi-Class Determination of 14 Coccidiostat Residues in Eggs and Chicken

被引：46

作者：

Shao, Bing ^{[1
,4
]}

Wu, Xiaoyan ^{[1
]}

Zhang, Jing ^{[1
]}

Duan, Hejun ^{[1
]}

Chu, Xiaogang ^{[2
]}

Wu, Yongning ^{[3
]}

机构：

[1] Beijing Ctr Dis Control & Prevent, Cent Lab, Beijing 100013, Peoples R China

[2] Chinese Acad Inspect & Quarantine, Beijing 100123, Peoples R China

[3] China Ctr Dis Control & Prevent, Inst Nutr & Food Safety, Beijing 100021, Peoples R China

[4] Capital Med Univ, Sch Publ Hlth & Family Med, Beijing 100089, Peoples R China

来源：

CHROMATOGRAPHIA | 2009年 / 69卷 / 9-10期

关键词：

Column liquid chromatography-tandem mass spectrometry; Coccidiostats; Eggs; Chicken; TANDEM MASS-SPECTROMETRY; LIQUID-CHROMATOGRAPHY; SALINOMYCIN; MONENSIN; FRAGMENTATION; BENZNIDAZOLE; MS/MS; FEED; MEAT;

D O I：

10.1365/s10337-009-1009-z

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This contribution presents a simple, rapid and sensitive method for determining the residues of a wide variety of coccidiostats in eggs and chicken. Fourteen target analytes from different classes with different polarities were simultaneously extracted from eggs and chicken using acetonitrile. Sample extracts were further concentrated and directly injected into a liquid chromatography system based on a C-18 column separation and acquired using electrospray ionization tandem mass spectrometry in the positive or negative mode. Recoveries based on matrix-fortified calibrations for eggs and chickens ranged from 78.0 to 125.2%. The limits of quantification for all analytes ranged from 0.1 to 0.2 mu g kg(-1).

引用

页码：1083 / 1088

页数：6

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