On the origin and frequency of Y chromosome deletions responsible for severe male infertility

被引：55

作者：

Edwards, RG ^{[1
]}

Bishop, CE ^{[1
]}

机构：

[1] BAYLOR COLL MED,DEPT MOL & HUMAN GENET,HOUSTON,TX 77030

来源：

MOLECULAR HUMAN REPRODUCTION | 1997年 / 3卷 / 07期

关键词：

deletions; meiosis; mosaicism; oligozoospermia; post-fertilization deletions;

D O I：

10.1093/molehr/3.7.549

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The origin of deletions associated with non-obstructive severe oligozoospermia in men are discussed. Deletions could arise during various stages of meiosis, at later stages in spermatids, or post-fertilization. Certain embryonic stages may be highly sensitive. The possibilities of an inherited propensity to these and other deletions, and of mosaicism in embryos are assessed.

引用

页码：549 / 554

页数：6

共 65 条

[11]

CHANDLEY AC, 1988, CYTOGENETICS MAMMALI, P361

[12] Identification of a hot spot for microdeletions in patients with X-linked deafness type 3 (DFN3) 900 kb proximal to the DFN3 gene POU3F4 [J].

deKok, YJM ;

Vossenaar, ER ;

Cremers, CWRJ ;

Dahl, N ;

Laporte, J ;

Hu, LJ ;

Lacombe, D ;

FischelGhodsian, N ;

Friedman, RA ;

Parnes, LS ;

Thorpe, P ;

BitnerGlindzicz, M ;

Pander, HJ ;

Heilbronner, H ;

Graveline, J ;

denDunnen, JT ;

Brunner, HG ;

Ropers, HH ;

Cremers, FPM .

HUMAN MOLECULAR GENETICS, 1996, 5 (09) :1229-1235

[13] The origin of genetic defects in the human and their detection in the preimplantation embryo [J].

Delhanty, JDA ;

Handyside, AH .

HUMAN REPRODUCTION UPDATE, 1995, 1 (03) :201-215

[14] Prevalence of 22q11 microdeletion [J].

duMontcel, ST ;

Mendizabal, H ;

Ayme, S ;

Levy, A ;

Philip, N .

JOURNAL OF MEDICAL GENETICS, 1996, 33 (08) :719-719

[15] THE TRANSITION FROM MATERNAL TO EMBRYONIC CONTROL IN THE 2-CELL MOUSE EMBRYO [J].

FLACH, G ;

JOHNSON, MH ;

BRAUDE, PR ;

TAYLOR, RAS ;

BOLTON, VN .

EMBO JOURNAL, 1982, 1 (06) :681-686

[16] XY PAIR ASSOCIATES WITH THE SYNAPTONEMAL COMPLEX OF AUTOSOMAL MALE-STERILE TRANSLOCATIONS IN PACHYTENE SPERMATOCYTES OF THE MOUSE (MUS-MUSCULUS) [J].

FOREJT, J ;

GREGOROVA, S ;

GOETZ, P .

CHROMOSOMA, 1981, 82 (01) :41-53

[17] IDENTIFICATION OF A 2ND PSEUDOAUTOSOMAL REGION NEAR THE XQ AND YQ TELOMERES [J].

FREIJE, D ;

HELMS, C ;

WATSON, MS ;

DONISKELLER, H .

SCIENCE, 1992, 258 (5089) :1784-1787

[18] Expression of the recombinase-activating gene (RAG-1) in murine early embryogenesis [J].

Hayakawa, S ;

Tochigi, M ;

Chishima, F ;

Shiraishi, H ;

Takahashi, N ;

Watanabe, K ;

Fujii, K ;

Satoh, K .

IMMUNOLOGY AND CELL BIOLOGY, 1996, 74 (01) :52-56

[19] COMPLEX GENE CONVERSION EVENTS IN GERMLINE MUTATION AT HUMAN MINISATELLITES [J].

JEFFREYS, AJ ;

TAMAKI, K ;

MACLEOD, A ;

MONCKTON, DG ;

NEIL, DL ;

ARMOUR, JAL .

NATURE GENETICS, 1994, 6 (02) :136-145

[20] The incidence and possible relevance of Y-linked microdeletions in babies born after intracytoplasmic sperm injection and their infertile fathers [J].

Kent-First, M. G. ;

Kol, S. ;

Muallem, A. ;

Ofir, R. ;

Manor, D. ;

Blazer, S. ;

First, N. ;

Itskovitz-Eldor, J. .

MOLECULAR HUMAN REPRODUCTION, 1996, 2 (12) :943-950

← 1 2 3 4 5 6 7 →