Linking CSF and cognition in Alzheimer's disease: Reanalysis of clinical data

被引:5
作者
Guhra, Michael [1 ]
Thomas, Christine [2 ]
Boedeker, Sebastian [1 ]
Kreisel, Stefan [1 ]
Driessen, Martin [1 ]
Beblo, Thomas [1 ]
Ohrmann, Patricia [3 ]
Toepper, Max [1 ]
机构
[1] Evangel Krankenhaus Bielefeld, Dept Psychiat & Psychotherapy Bethel, D-33617 Bielefeld, Germany
[2] Clin Ctr Stuttgart, Clin Psychiat & Psychotherapy Elderly, D-70374 Stuttgart, Germany
[3] Univ Munster, Dept Psychiat, D-48149 Munster, Germany
关键词
Alzheimer's disease; Cerebrospinal fluid; Biomarkers; Amyloid beta; Tau; Cognition; Memory; Executive function; CEREBROSPINAL-FLUID LEVELS; EXECUTIVE FUNCTION; TAU-PROTEIN; HYPOTHETICAL MODEL; DYNAMIC BIOMARKERS; FALSE RECOGNITION; OLDER-ADULTS; IMPAIRMENT; MEMORY; DEMENTIA;
D O I
10.1016/j.exger.2015.11.008
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objectives: Memory and executive deficits are important cognitive markers of Alzheimer's disease (AD). Moreover, in the past decade, cerebrospinal fluid (CSF) biomarkers have been increasingly utilized in clinical practice. Both cognitive and CSF markers can be used to differentiate between AD patients and healthy seniors with high diagnostic accuracy. However, the extent to which performance on specific mnemonic or executive tasks enables reliable estimations of the concentrations of different CSF markers and their ratios remains unclear. Methods: To address the above issues, we examined the association between neuropsychological data and CSF biomarkers in 51 AD patients using hierarchical multiple regression analyses. In the first step of these analyses, age, education and sex were entered as predictors to control for possible confounding effects. In the second step, data from a neuropsychological test battery assessing episodic memory, semantic memory and executive functioning were included to determine whether these variables significantly increased (compared to step 1) the explained variance in A beta(42) concentration, p-tau concentration, t-tau concentration, A beta(42)/t-tau ratio, and A beta(42)/A beta(40) ratio. Results: The different models explained 52% of the variance in A beta(42)/t-tau ratio, 27% of the variance in A beta(42) concentration, and 28% of the variance in t-tau concentration. In particular, A beta(42)/t-tau ratio was associated with verbal recognition and code shifting, with A beta(42) being related to verbal recognition and t-tau being related to code shifting. By contrast, the inclusion of neuropsychological data did not allow reliable estimations of A beta(42)/A beta(40) ratio or p-tau concentration. Conclusion: Our results showed that strong associations exist between the cognitive key symptoms of AD and the concentrations and ratios of specific CSF markers. In addition, we revealed a specific combination of neuropsychological tests that may facilitate reliable estimations of CSF concentrations, thereby providing important diagnostic information for non-invasive early AD detection. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:107 / 113
页数:7
相关论文
共 50 条
[21]   Recognizing Atypical Presentations of Alzheimer's Disease: The Importance of CSF Biomarkers in Clinical Practice [J].
Paraskevas, George P. P. ;
Constantinides, Vasilios C. C. ;
Boufidou, Fotini ;
Tsantzali, Ioanna ;
Pyrgelis, Efstratios-Stylianos ;
Liakakis, Georgios ;
Kapaki, Elisabeth .
DIAGNOSTICS, 2022, 12 (12)
[22]   Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial [J].
Craft, Suzanne ;
Claxton, Amy ;
Baker, Laura D. ;
Hanson, Angela J. ;
Cholerton, Brenna ;
Trittschuh, Emily H. ;
Dahl, Deborah ;
Caulder, Erin ;
Neth, Bryan ;
Montine, Thomas J. ;
Jung, Youngkyoo ;
Maldjian, Joseph ;
Whitlow, Christopher ;
Friedman, Seth .
JOURNAL OF ALZHEIMERS DISEASE, 2017, 57 (04) :1325-1334
[23]   White matter hyperintensity topography in Alzheimer's disease and links to cognition [J].
Garnier-Crussard, Antoine ;
Bougacha, Salma ;
Wirth, Miranka ;
Dautricourt, Sophie ;
Sherif, Siya ;
Landeau, Brigitte ;
Gonneaud, Julie ;
De Flores, Robin ;
de la Sayette, Vincent ;
Vivien, Denis ;
Krolak-Salmon, Pierre ;
Chetelat, Gael .
ALZHEIMERS & DEMENTIA, 2022, 18 (03) :422-433
[24]   Prediction of Preclinical Alzheimer's Disease: Longitudinal Rates of Change in Cognition [J].
Riley, Kathryn P. ;
Jicha, Gregory A. ;
Davis, Daron ;
Abner, Erin L. ;
Cooper, Gregory E. ;
Stiles, Nancy ;
Smith, Charles D. ;
Kryscio, Richard J. ;
Nelson, Peter T. ;
Van Eldik, Linda J. ;
Schmitt, Frederick A. .
JOURNAL OF ALZHEIMERS DISEASE, 2011, 25 (04) :707-717
[25]   Current status of cognition-based interventions in Alzheimer's disease [J].
Buschert, V. C. ;
Teipel, S. J. ;
Hampel, H. ;
Buerger, K. .
NERVENARZT, 2009, 80 (03) :273-+
[26]   Functional Network Alterations Associated with Cognition in Pre-Clinical Alzheimer's Disease [J].
Fountain-Zaragoza, Stephanie ;
Liu, Hesheng ;
Benitez, Andreana .
BRAIN CONNECTIVITY, 2023, 13 (05) :275-286
[27]   CSF Ubiquitin As a Specific Biomarker in Alzheimer's Disease [J].
Kandimalla, Ramesh J. ;
Anand, R. ;
Veeramanikandan, R. ;
Wani, Willayat Yousuf ;
Prabhakar, Sudesh ;
Grover, Vinod K. ;
Bharadwaj, Neerja ;
Jain, Kajal ;
Gill, Kiran Dip .
CURRENT ALZHEIMER RESEARCH, 2014, 11 (04) :340-348
[28]   Alzheimer's Disease-Associated Cerebrospinal Fluid (CSF) Biomarkers do not Correlate with CSF Volumes or CSF Production Rate [J].
Edsbagge, Mikael ;
Andreasson, Ulf ;
Ambarki, Khalid ;
Wikkelso, Carsten ;
Eklund, Anders ;
Blennow, Kaj ;
Zetterberg, Henrik ;
Tullberg, Mats .
JOURNAL OF ALZHEIMERS DISEASE, 2017, 58 (03) :821-828
[29]   Association of Basal Forebrain Volume with Amyloid, Tau, and Cognition in Alzheimer's Disease [J].
Yoo, Han Soo ;
Kim, Han-Kyeol ;
Lee, Jae-Hoon ;
Chun, Joong-Hyun ;
Lee, Hye Sun ;
Grothe, Michel J. ;
Teipel, Stefan ;
Cavedo, Enrica ;
Vergallo, Andrea ;
Hampel, Harald ;
Ryu, Young Hoon ;
Cho, Hanna ;
Lyoo, Chul Hyoung .
JOURNAL OF ALZHEIMERS DISEASE, 2024, 99 (01) :145-159
[30]   The correlation of everyday cognition test scores and the progression of Alzheimer's disease: a data analytics study [J].
Thabtah, Fadi ;
Spencer, Robinson ;
Ye, Yongsheng .
HEALTH INFORMATION SCIENCE AND SYSTEMS, 2020, 8 (01)