Enantioselective construction of quaternary carbon centre catalysed by bifunctional organocatalyst

被引：143
作者：
Liu, Tian-Yu
Long, Jun
Li, Bang-Jing
Jiang, Lin
Li, Rui
Wu, Yong
Ding, Li-Sheng
Chen, Ying-Chun [1 ]
机构：
[1] Sichuan Univ, Educ Minist, Key Lab Drug Targeting, Chengdu 610041, Peoples R China
[2] Sichuan Univ, W China Sch Pharm, Dept Med Chem, Chengdu 610041, Peoples R China
[3] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 11期
关键词：
D O I：
10.1039/b605871j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The bifunctional thiourea - tertiary amine derivatives of simple chiral diamines serve as highly enantioselective catalysts for the Michael addition of alpha-substituted cyanoacetates to vinyl sulfones, giving an efficient protocol for the construction of an all-carbon substituted quaternary stereocentre.
引用
收藏
页码：2097 / 2099
页数：3
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