The Renin Angiotensin Aldosterone System in Obesity and Hypertension Roles in the Cardiorenal Metabolic Syndrome

被引：121

作者：

Cabandugama, Peminda K. ^{[1
]}

Gardner, Michael J. ^{[1
]}

Sowers, James R. ^{[1
,2
,3
]}

机构：

[1] Univ Missouri, Dept Med, Diabet & Cardiovasc Ctr, Div Endocrinol, D109 Diabet Ctr UHC,One Hosp Dr, Columbia, MO 65212 USA

[2] Univ Missouri, Dept Physiol & Pharmacol, One Hosp Dr, Columbia, MO 65212 USA

[3] Harry S Truman VA Hosp, 800 Hosp Dr, Columbia, MO 65201 USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2017年 / 101卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Obesity; Insulin resistance; Angiotensin II; Adipocyte; Hypertension; ADIPOSE-TISSUE; SYMPATHETIC ACTIVATION; INSULIN-RESISTANCE; DIABETES-MELLITUS; LEPTIN; INHIBITION; DIET; DEFICIENCY; SOCIETY;

D O I：

10.1016/j.mcna.2016.08.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the United States, more than 50 million people have blood pressure at or above 120/80 mm Hg. All components of cardiorenal metabolic syndrome (CRS) are linked to metabolic abnormalities and obesity. A major driver for CRS is obesity. Current estimates show that many of those with hypertension and CRS show some degree of systemic and cardiovascular insulin resistance. Several pathophysiologic factors participate in the link between hypertension and CRS. This article updates recent literature with a focus on the function of insulin resistance, obesity, and renin angiotensin aldosterone system-mediated oxidative stress on endothelial dysfunction and the pathogenesis of hypertension.

引用

页码：129 / +

页数：11

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