Composite Hydrogels of Bacterial Cellulose - carboxymethyl Cellulose for Drug Release

被引：0

作者：

Pavaloiu, Ramona-Daniela ^{[1
]}

Stroescu, Marta ^{[1
]}

Parvulescu, Oana ^{[1
]}

Dobre, Tanase ^{[1
]}

机构：

[1] Univ Politehn of Bucharest, Fac Appl Chem & Mat Sci, Bucharest 011061, Romania

来源：

REVISTA DE CHIMIE | 2014年 / 65卷 / 08期

关键词：

bacterial cellulose; carboxymethyl cellulose; drug release; ibuprofen sodium salt;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bacterial-cellulose (BC) is a suitable material for biomedical applications due to its remarkable proprieties, such us: biodegradability, biocompatibility and ready availability. In this paper the swelling and drug release profiles from bacterial cellulose- carboxymethyl cellulose (BC-CMC) composite hydrogels were investigated, in the aim to use such systems in controlled drug delivery field Ibuprofen sodium salt (IbuNa) was used as model drug. The obtained results revealed that carboxymethyl cellulose content and epichlorohydrin concentration, used as crosslinker agent, influence both swelling and drug release properties. Also, the swelling mechanism was studied and found to be governed by pseudo-Fickian diffusion. These preliminary findings suggest that BC-CMC hydrogels could be exploited as components in controlled delivery systems.

引用

页码：948 / 951

页数：4

共 19 条

[1] Improving bacterial cellulose for blood vessel replacement: Functionalization with a chimeric protein containing a cellulose-binding module and an adhesion peptide [J].

Andrade, Fabia K. ;

Costa, Raquel ;

Domingues, Lucilia ;

Soares, Raquel ;

Gama, Miguel .

ACTA BIOMATERIALIA, 2010, 6 (10) :4034-4041

[2]

Bostan L, 2010, REV CHIM-BUCHAREST, V61, P1235

[3]

Cairul M., 2012, CARBOHYD POLYM, V88, P465

[4] Effects of CMC Addition on Bacterial Cellulose Production in a Biofilm Reactor and Its Paper Sheets Analysis [J].

Cheng, Kuan-Chen ;

Catchmark, Jeffrey M. ;

Demirci, Ali .

BIOMACROMOLECULES, 2011, 12 (03) :730-736

[5] Characterization and biocompatibility of bacterial cellulose/alginate composite sponges with human keratinocytes and gingival fibroblasts [J].

Chiaoprakobkij, Nadda ;

Sanchavanakit, Neeracha ;

Subbalekha, Keskanya ;

Pavasant, Prasit ;

Phisalaphong, Muenduen .

CARBOHYDRATE POLYMERS, 2011, 85 (03) :548-553

[6]

Ciechanska D, 2004, FIBRES TEXT EAST EUR, V12, P69

[7] The future prospects of microbial cellulose in biomedical applications [J].

Czaja, Wojciech K. ;

Young, David J. ;

Kawecki, Marek ;

Brown, R. Malcolm, Jr. .

BIOMACROMOLECULES, 2007, 8 (01) :1-12

[8]

Dobre LM, 2012, REV CHIM-BUCHAREST, V63, P540

[9]

Dobre T, 2008, REV CHIM-BUCHAREST, V59, P591

[10]

Flory P. J., 1943, J CHEM PHYS, V11, P521, DOI DOI 10.1063/1.1723792

← 1 2 →