Moderate Hypobaric Hypoxia Modifies Ca2+-Mediated Glutamatergic Signal Transduction in Rat Cerebral Cortex

被引：5
|
作者：
Semenov, D. G. [1 ]
Belyakov, A. V. [1 ]
Samoilov, M. O. [1 ]
机构：
[1] Russian Acad Sci, IP Pavlov Physiol Inst, St Petersburg 196140, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2009年 / 147卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
hypobaric hypoxia; glutamate; calcium; preconditioning; TOLERANCE;
D O I：
10.1007/s10517-009-0467-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Examination of fluorescent Ca2+-responses to stimulation by ionotropic glutamate receptor agonists in rat cerebral cortex slices, preconditioned with hypobaric hypoxia, has demonstrated different time course for up-regulation of their Ca2+-conductivity and for stimulation of the consequent binding of the Ca2+ which entered the cell. The evident result is the development of AMPA-mediated moderate increase of intracellular Ca2+.
引用
收藏
页码：185 / 188
页数：4
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