Synthesis and 5-HT 1A affinity of an optically active benzodioxane derivative MKC-242; A novel anxiolytic and antidepressant agent

被引:0
|
作者
Yamabe, H [1 ]
Sugano, M [1 ]
Chaki, H [1 ]
Abe, M [1 ]
Tabata, R [1 ]
Saito, KI [1 ]
机构
[1] MITSUBISHI CHEM CORP,YOKOHAMA RES CTR,AOBA KU,YOKOHAMA,KANAGAWA 227,JAPAN
来源
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 1997年 / 214卷
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:19 / MEDI
页数:1
相关论文
共 23 条
  • [1] MKC-242 -: Anxiolytic -: Antidepressant -: 5-HT1A agonist
    不详
    DRUGS OF THE FUTURE, 2001, 26 (03) : 303 - 303
  • [2] Reduction of wrap restraint stress-induced defecation by MKC-242, a novel benzodioxan derivative, via 5-HT1A-receptor agonist action in rats
    Abe, M
    Saito, KI
    JAPANESE JOURNAL OF PHARMACOLOGY, 1998, 77 (03): : 211 - 217
  • [3] THE DEVELOPMENT OF SELECTIVE POSTSYNAPTIC 5-HT(1A) AGONISTS AS NOVEL ANTIDEPRESSANT AGENTS
    DEMONTIGNY, C
    HADRAVA, V
    ORTEMANN, C
    LISTA, A
    BLIER, P
    NEUROPSYCHOPHARMACOLOGY, 1993, 9 (02) : S9 - S10
  • [4] S-14506 - A NOVEL, POTENT, HIGH-EFFICACY 5-HT(1A) AGONIST AND POTENTIAL ANXIOLYTIC AGENT
    COLPAERT, FC
    KOEK, W
    LEHMANN, J
    RIVET, JM
    LEJEUNE, F
    CANTON, H
    BERVOETS, K
    MILLAN, MJ
    LAUBIE, M
    LAVIELLE, G
    DRUG DEVELOPMENT RESEARCH, 1992, 26 (01) : 21 - 48
  • [5] STIMULATION OF HIPPOCAMPAL 5-HT(1A)-RECEPTORS CAUSES AMNESIA AND ANXIOLYTIC-LIKE BUT NOT ANTIDEPRESSANT-LIKE EFFECTS IN THE RAT
    CARLI, M
    TATARCZYNSKA, E
    CERVO, L
    SAMANIN, R
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 234 (2-3) : 215 - 221
  • [6] Novel benzodioxan derivative, 5-{3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy}-1,3-benzodioxole HCl (MKC-242), with anxiolytic-like and antidepressant-like effects in animal models
    Abe, M
    Tabata, R
    Saito, K
    Matsuda, T
    Baba, A
    Egawa, M
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1996, 278 (02): : 898 - 905
  • [7] MKC-242, a novel 5-HT1A receptor agonist, facilitates cortical acetylcholine release by a mechanism different from that of 8-OH-DPAT in awake rats
    Somboonthum, P
    Matsuda, T
    Asano, S
    Sakaue, M
    Baba, A
    NEUROPHARMACOLOGY, 1997, 36 (11-12) : 1733 - 1739
  • [8] DIAZEPAM PRODUCES PARTIAL GENERALIZATION TO THE DISCRIMINATIVE STIMULUS EFFECTS OF WAY-SEB-324, A 5-HT(1A) PARTIAL AGONIST/5-HT2 ANTAGONIST ANXIOLYTIC ANTIDEPRESSANT
    SHROPSHIRE, AT
    PIESLA, MJ
    MOYER, JA
    MARQUIS, KL
    FASEB JOURNAL, 1993, 7 (03): : A256 - A256
  • [9] Effects of a benzodioxan derivative MKC-242 on the firing activity of the dorsal hippocampus CA1 pyramidal neurons in awake and urethane-anaesthetized rats:: in vivo electrophysiological evidence for a 5-HT1A agonistic property
    Kasamo, K
    Suzuki, T
    Tada, K
    Ueba, N
    Matsuda, E
    Kojima, T
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2000, 3 (02): : 99 - 108
  • [10] 6-Acetyl-5-hydroxy-4,7-dimethylcoumarin derivatives: Design, synthesis, modeling studies, 5-HT 1A, 5-HT 2A and D 2 receptors affinity
    Ostrowska, Kinga
    Lesniak, Anna
    Karczynska, Urszula
    Jeleniewicz, Paulina
    Gluch-Lutwin, Monika
    Mordyl, Barbara
    Siwek, Agata
    Trzaskowski, Bartosz
    Sacharczuk, Mariusz
    Bujalska-Zadrozny, Magdalena
    BIOORGANIC CHEMISTRY, 2020, 100