Visualization of tumor-related blood vessels in human breast by photoacoustic imaging system with a hemispherical detector array

被引：214

作者：

Toi, M. ^{[1
]}

Asao, Y. ^{[1
,2
]}

Matsumoto, Y. ^{[1
]}

Sekiguchi, H. ^{[3
]}

Yoshikawa, A. ^{[1
]}

Takada, M. ^{[1
]}

Kataoka, M. ^{[3
]}

Endo, T. ^{[2
]}

Kawaguchi-Sakita, N. ^{[1
]}

Kawashima, M. ^{[1
]}

Fakhrejahani, E. ^{[1
]}

Kanao, S. ^{[3
]}

Yamaga, I. ^{[1
]}

Nakayama, Y. ^{[1
]}

Tokiwa, M. ^{[1
]}

Torii, M. ^{[1
]}

Yagi, T. ^{[2
]}

Sakurai, T. ^{[4
]}

Togashi, K. ^{[2
]}

Shiina, T. ^{[5
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Breast Surg, Sakyo Ku, 54 Shogoin Kawaharacho, Kyoto 6068507, Japan

[2] Canon Inc, Med Imaging Syst Dev Ctr, Ohta Ku, 3-30-2 Shimomaruko, Tokyo 1468501, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Diagnost Imaging & Nucl Med, Sakyo Ku, 54 Shogoin Kawaharacho, Kyoto 6068507, Japan

[4] Kyoto Univ, Grad Sch Med, Dept Diagnost Pathol, Sakyo Ku, 54 Shogoin Kawaharacho, Kyoto 6068507, Japan

[5] Kyoto Univ, Grad Sch Med, Dept Human Hlth Sci, Sakyo Ku, 53 Shogoin Kawaharacho, Kyoto 6068507, Japan

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

TOMOGRAPHY;

D O I：

10.1038/srep41970

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Noninvasive measurement of the distribution and oxygenation state of hemoglobin (Hb) inside the tissue is strongly required to analyze the tumor-associated vasculatures. We developed a photoacoustic imaging (PAI) system with a hemispherical-shaped detector array (HDA). Here, we show that PAI system with HDA revealed finer vasculature, more detailed blood-vessel branching structures, and more detailed morphological vessel characteristics compared with MRI by the use of breast shape deformation of MRI to PAI and their fused image. Morphologically abnormal peritumoral blood vessel features, including centripetal photoacoustic signals and disruption or narrowing of vessel signals, were observed and intratumoral signals were detected by PAI in breast cancer tissues as a result of the clinical study of 22 malignant cases. Interestingly, it was also possible to analyze anticancer treatment-driven changes in vascular morphological features and function, such as improvement of intratumoral blood perfusion and relevant changes in intravascular hemoglobin saturation of oxygen. This clinical study indicated that PAI appears to be a promising tool for noninvasive analysis of human blood vessels and may contribute to improve cancer diagnosis.

引用

页数：11

共 24 条

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