Transforming growth factor α, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas

被引：1
作者：
D'Antonio, A
Losito, S
Pignata, S
Grassi, M
Perrone, F
De Luca, A
Tambaro, R
Bianco, C
Gullick, WJ
Johnson, GR
Iaffaioli, VR
Salomon, DS
Normanno, N [1 ]
机构：
[1] ITN Fdn Pascale, Serv Oncol Spimentale D, I-80131 Naples, Italy
[2] ITN Fdn Pascale, Serv Anat Patol, I-80131 Naples, Italy
[3] ITN Fdn Pascale, Div Oncol Med B, I-80131 Naples, Italy
[4] ITN Fdn Pascale, Ufficio Sperimentaz Clin Controllate, I-80131 Naples, Italy
[5] AORN Cardarelli, Naples, Italy
[6] NCI, Tumor Growth Factor Sect, Basic Res Lab, NIH, Bethesda, MD 20892 USA
[7] Univ Kent, Dept Biosci, Canterbury CT2 7NJ, Kent, England
[8] US FDA, DTP, Bethesda, MD 20892 USA
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 2002年 / 21卷 / 05期
关键词：
cripto-1; amphiregulin; TGF alpha; ovarian cancer; prognosis;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The expression of transforming growth factor alpha (TGFalpha), amphiregulin (AR) and cripto-1 (CR-1) was assessed by immunohistochemistry in 83 specimens (59 primary ovarian tumors and 24 extra-ovarian carcinomas) that were obtained from 68 ovarian carcinoma patients. Within the 59 primary tumors, 54 (92%) expressed immunoreactive TGFalpha, 45 (76%) expressed AR, and 28 (47%) expressed CR-1. The expression of AR and CR-1 mRNAs in the ovarian carcinomas was also demonstrated by RT-PCR analysis. Seventeen extra-ovarian specimens (71%) were found to express CR-1, whereas AR and TGFalpha were expressed respectively in 21 (87%) and 22 (92%) extra-ovarian tissues. In 15 cases for whom both ovarian and extra-ovarian tissues were available, a statistically significant higher expression of CR-1 was found in extra-ovarian specimens. A statistically significant correlation was found between AR expression in the ovarian carcinomas and both low grade and low proliferative activity. Finally, expression of TGFalpha was predictive of longer progression-free survival. These data strongly suggest that the EGF-related peptides might be involved in the pathogenesis and outcome of human ovarian cancer.
引用
收藏
页码：941 / 948
页数：8
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