Transforming growth factor α, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas

被引：1

作者：

D'Antonio, A

Losito, S

Pignata, S

Grassi, M

Perrone, F

De Luca, A

Tambaro, R

Bianco, C

Gullick, WJ

Johnson, GR

Iaffaioli, VR

Salomon, DS

Normanno, N ^{[1
]}

机构：

[1] ITN Fdn Pascale, Serv Oncol Spimentale D, I-80131 Naples, Italy

[2] ITN Fdn Pascale, Serv Anat Patol, I-80131 Naples, Italy

[3] ITN Fdn Pascale, Div Oncol Med B, I-80131 Naples, Italy

[4] ITN Fdn Pascale, Ufficio Sperimentaz Clin Controllate, I-80131 Naples, Italy

[5] AORN Cardarelli, Naples, Italy

[6] NCI, Tumor Growth Factor Sect, Basic Res Lab, NIH, Bethesda, MD 20892 USA

[7] Univ Kent, Dept Biosci, Canterbury CT2 7NJ, Kent, England

[8] US FDA, DTP, Bethesda, MD 20892 USA

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2002年 / 21卷 / 05期

关键词：

cripto-1; amphiregulin; TGF alpha; ovarian cancer; prognosis;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The expression of transforming growth factor alpha (TGFalpha), amphiregulin (AR) and cripto-1 (CR-1) was assessed by immunohistochemistry in 83 specimens (59 primary ovarian tumors and 24 extra-ovarian carcinomas) that were obtained from 68 ovarian carcinoma patients. Within the 59 primary tumors, 54 (92%) expressed immunoreactive TGFalpha, 45 (76%) expressed AR, and 28 (47%) expressed CR-1. The expression of AR and CR-1 mRNAs in the ovarian carcinomas was also demonstrated by RT-PCR analysis. Seventeen extra-ovarian specimens (71%) were found to express CR-1, whereas AR and TGFalpha were expressed respectively in 21 (87%) and 22 (92%) extra-ovarian tissues. In 15 cases for whom both ovarian and extra-ovarian tissues were available, a statistically significant higher expression of CR-1 was found in extra-ovarian specimens. A statistically significant correlation was found between AR expression in the ovarian carcinomas and both low grade and low proliferative activity. Finally, expression of TGFalpha was predictive of longer progression-free survival. These data strongly suggest that the EGF-related peptides might be involved in the pathogenesis and outcome of human ovarian cancer.

引用

页码：941 / 948

页数：8

共 35 条

[1] Cripto: A tumor growth factor and more
Adamson, ED
Minchiotti, G
Salomon, DS
[J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2002, 190 (03) : 267 - 278
[2] BAUKNECHT T, 1993, CANCER, V71, P419, DOI 10.1002/1097-0142(19930115)71:2<419::AID-CNCR2820710224>3.0.CO
[3] 2-6
[4] Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial cells
Bianco, C
Adkins, HB
Wechselberger, C
Seno, M
Normanno, N
De Luca, A
Sun, YP
Khan, N
Kenney, N
Ebert, A
Williams, KP
Sanicola, M
Salomon, DS
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (08) : 2586 - 2597
[5] EGF-related antisense oligonucleotides inhibit the proliferation of human ovarian carcinoma cells
Casamassimi, A
De Luca, A
Agrawal, S
Stromberg, K
Salomon, DS
Normanno, N
[J]. ANNALS OF ONCOLOGY, 2000, 11 (03) : 319 - 325
[6] EPIDERMAL GROWTH-FACTOR REGULATES THE INVITRO SENSITIVITY OF HUMAN OVARIAN-CARCINOMA CELLS TO CISPLATIN
CHRISTEN, RD
HOM, DK
PORTER, DC
ANDREWS, PA
MACLEOD, CL
HAFSTROM, L
HOWELL, SB
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (05) : 1632 - 1640
[7] MITOGENIC EFFECTS OF EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH FACTOR-ALPHA ON EGF-RECEPTOR POSITIVE HUMAN OVARIAN-CARCINOMA CELL-LINES
CREW, AJ
LANGDON, SP
MILLER, EP
MILLER, WR
[J]. EUROPEAN JOURNAL OF CANCER, 1992, 28A (2-3) : 337 - 341
[8] De Angelis E, 1999, INT J ONCOL, V14, P437
[9] Simultaneous blockade of different EGF-like growth factors results in efficient growth inhibition of human colon carcinoma xenografts
De Luca, A
Arra, C
D'Antonio, A
Casamassimi, A
Losito, S
Ferraro, P
Ciardiello, F
Salomon, DS
Normanno, N
[J]. ONCOGENE, 2000, 19 (51) : 5863 - 5871
[10] De Luca A, 1999, INT J CANCER, V80, P589, DOI 10.1002/(SICI)1097-0215(19990209)80:4<589::AID-IJC17>3.3.CO

← 1 2 3 4 →