The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4

被引：348
|
作者：
Seenisamy, J
Rezler, EM
Powell, TJ
Tye, D
Gokhale, V
Joshi, CS
Siddiqui-Jain, A
Hurley, LH
机构：
[1] Univ Arizona, Coll Pharm, Tucson, AZ 85721 USA
[2] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA
[3] Cylene Pharmaceut, San Diego, CA 92121 USA
[4] Arizona Canc Ctr, Tucson, AZ 85724 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 28期
关键词：
D O I：
10.1021/ja040022b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The nuclease hypersensitivity element III1 (NHE III1) upstream of the P1 and P2 promoters of c-MYC controls 80-90% of the transcriptional activity of this gene. The purine-rich strand in this region can form a G-quadruplex structure that is a critical part of the silencer element for this promoter. We have demonstrated that this G-quadruplex structure can form a mixture of four biologically relevant parallel-loop isomers, which upon interaction with the cationic porphyrin TMPyP4 are converted to mixed parallel/antiparallel G-quadruplex structures.
引用
收藏
页码：8702 / 8709
页数：8
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