Amyloid β aggregation inhibitory activity of triterpene saponins from the cactus Stenocereus pruinosus

被引：15

作者：

Fujihara, Koji ^{[1
]}

Shimoyama, Takuya ^{[1
]}

Kawazu, Ryo ^{[1
]}

Sasaki, Hiroaki ^{[1
]}

Koyama, Kiyotaka ^{[1
]}

Takahashi, Kunio ^{[1
]}

Kinoshita, Kaoru ^{[1
]}

机构：

[1] Meiji Pharmaceut Univ, Dept Pharmacognosy & Phytochem, 2-522-1 Noshio, Kiyose, Tokyo 2048588, Japan

来源：

JOURNAL OF NATURAL MEDICINES | 2021年 / 75卷 / 02期

关键词：

Cactus; Stenocereus pruinosus; Saponins; Alzheimer's disease; Amyloid beta; BACE1; ALZHEIMERS-DISEASE; PROTEIN; SECRETASE; PLANTS;

D O I：

10.1007/s11418-020-01463-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new triterpene saponins (1-5,7) and 3 known saponins (6,8,9) were isolated from MeOH extracts of the cactus Stenocereus pruinosus. The structures of the isolated saponins were elucidated using MS, IR, and comprehensive NMR measurements. To develop drugs for treating Alzheimer's disease (AD) on the basis of the amyloid cascade hypothesis, the isolated saponins were evaluated for inhibition of BACE1 activity and amyloid beta (A beta) aggregation using thioflavin-T assay, and triterpenes as an aglycone moiety and an alkaline hydrolysate of the saponins were also evaluated. One saponin, stenoside A (7), exhibited inhibitory activity related to A beta aggregation and its degree of A beta aggregation was 40.6% at 100 mu M. Graphic abstract

引用

页码：284 / 298

页数：15

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