Amyloid β aggregation inhibitory activity of triterpene saponins from the cactus Stenocereus pruinosus

被引:15
作者
Fujihara, Koji [1 ]
Shimoyama, Takuya [1 ]
Kawazu, Ryo [1 ]
Sasaki, Hiroaki [1 ]
Koyama, Kiyotaka [1 ]
Takahashi, Kunio [1 ]
Kinoshita, Kaoru [1 ]
机构
[1] Meiji Pharmaceut Univ, Dept Pharmacognosy & Phytochem, 2-522-1 Noshio, Kiyose, Tokyo 2048588, Japan
关键词
Cactus; Stenocereus pruinosus; Saponins; Alzheimer's disease; Amyloid beta; BACE1; ALZHEIMERS-DISEASE; PROTEIN; SECRETASE; PLANTS;
D O I
10.1007/s11418-020-01463-0
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Six new triterpene saponins (1-5,7) and 3 known saponins (6,8,9) were isolated from MeOH extracts of the cactus Stenocereus pruinosus. The structures of the isolated saponins were elucidated using MS, IR, and comprehensive NMR measurements. To develop drugs for treating Alzheimer's disease (AD) on the basis of the amyloid cascade hypothesis, the isolated saponins were evaluated for inhibition of BACE1 activity and amyloid beta (A beta) aggregation using thioflavin-T assay, and triterpenes as an aglycone moiety and an alkaline hydrolysate of the saponins were also evaluated. One saponin, stenoside A (7), exhibited inhibitory activity related to A beta aggregation and its degree of A beta aggregation was 40.6% at 100 mu M. Graphic abstract
引用
收藏
页码:284 / 298
页数:15
相关论文
共 48 条
[1]   Alzheimer's disease: An overview of amyloid beta dependent pathogenesis and its therapeutic implications along with in silico approaches emphasizing the role of natural products [J].
Awasthi, Manika ;
Singh, Swati ;
Pandey, Veda P. ;
Dwivedi, Upendra N. .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2016, 361 :256-271
[2]   Dammarane triterpenoid glycosides in Bacopa monnieri: A review on chemical diversity and bioactivity [J].
Bhandari, Pamita ;
Sendri, Nitisha ;
Devidas, Shinde Bhagatsing .
PHYTOCHEMISTRY, 2020, 172
[3]  
BOCK K, 1973, TETRAHEDRON LETT, P1037
[4]   MOLLUSCICIDAL SAPONINS FROM SWARTZIA-SIMPLEX [J].
BOREL, C ;
GUPTA, MP ;
HOSTETTMANN, K .
PHYTOCHEMISTRY, 1987, 26 (10) :2685-2689
[5]   Anti-amyloid Aggregation Activity of Natural Compounds: Implications for Alzheimer's Drug Discovery [J].
Bu, Xian-Le ;
Rao, Praveen P. N. ;
Wang, Yan-Jiang .
MOLECULAR NEUROBIOLOGY, 2016, 53 (06) :3565-3575
[6]  
Casas Alejandro, 1999, Journal of Ethnobiology, V19, P71
[7]   Exploring the efficacy of natural products in alleviating Alzheimer's disease [J].
Deshpande, Prajakta ;
Gogia, Neha ;
Singh, Amit .
NEURAL REGENERATION RESEARCH, 2019, 14 (08) :1321-1329
[8]   Harpuloside a triterpenoid saponin from Harpullia ramiflora [J].
Dizes, C ;
Gerald, F ;
Lavaud, C ;
Elias, R ;
Faure, R ;
Massiot, G ;
Balansard, G .
PHYTOCHEMISTRY, 1998, 48 (07) :1229-1232
[9]   TERPENOIDS .11. INVESTIGATION OF NINE CACTUS SPECIES - ISOLATION OF 2 NEW TRITERPENES, STELLATOGENIN AND MACHAERIC ACID [J].
DJERASSI, C ;
LIU, LH ;
FARKAS, E ;
LIPPMAN, AE ;
LEMIN, AJ ;
GELLER, LE ;
MCDONALD, RN ;
TAYLOR, BJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1955, 77 (05) :1200-1203
[10]   Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells [J].
Fujihara, Koji ;
Takahashi, Kunio ;
Koyama, Kiyotaka ;
Kinoshita, Kaoru .
JOURNAL OF NATURAL MEDICINES, 2017, 71 (04) :606-616