Epidemiological, clinical, and pathological aspects of diminazene aceturate toxicosis in dogs

被引:4
作者
Flores, Mariana M. [1 ]
Pereira, Paula R. [2 ]
Mazzanti, Alexandre [3 ]
Kommers, Glaucia D. [4 ]
Fighera, Rafael A. [4 ]
机构
[1] Univ Fed Santa Maria, CCR, Programa Posgrad Med Vet, Area Concentracao Patol Vet, BR-97105900 Santa Maria, RS, Brazil
[2] Univ Fed Santa Maria, CCR, Curso Med Vet, BR-97105900 Santa Maria, RS, Brazil
[3] Univ Fed Santa Maria, CCR, Hosp Vet Univ, Serv Neurol,Dept Clin Pequenos Anim, BR-97105900 Santa Maria, RS, Brazil
[4] Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Patol, BR-97105900 Santa Maria, RS, Brazil
来源
PESQUISA VETERINARIA BRASILEIRA | 2014年 / 34卷 / 07期
关键词
Diseases of dogs; toxicosis; toxicology; antiprotozoal therapy; diminazene aceturate; TRYPANOSOMA-CONGOLENSE; CANINE BABESIOSIS; BRUCEI INFECTION; HEALTHY; PHARMACOKINETICS; CHEMOTHERAPY; PENTAMIDINE; RESISTANT; STRAIN;
D O I
10.1590/S0100-736X2014000700011
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The epidemiological, clinical, and pathological aspects of diminazene aceturate (DA) spontaneous toxicosis were evaluated in 10 dogs. All affected dogs developed signs of thalamic-cortical syndrome, characterized mainly by neurological changes in the conscience levels, tetraparesis, extensor stiffness, and seizures. In some cases there was also evidence of cerebellar syndrome, characterized by generalized muscle tremors (high-frequency and low-amplitude) and/or vestibular syndrome, characterized by or ataxia, head tilt, and falling. These clinical signs occurred between 24 and 48 hours following intramuscular administration of DA and persisted until spontaneous death or euthanasia occurred between 1 and 7 days after the onset of clinical signs. The mentioned clinical signs reflected lesions that consisted of focal symmetrical hemorrhagic encephalomalacia affecting medulla oblongata, pons, cerebellar medulla, thalamus, midbrain, cerebellar peduncles, and basal nuclei. This article (1) describes and discusses DA toxicosis in dogs, a poorly-described clinical entity that is unknown by most clinicians and pathologists in Brazil; (2) establishes the clinical and pathological criteria for the diagnosis of DA toxicosis in dogs; and (3) calls up the attention for the risks of using DA in dogs in clinical settings.
引用
收藏
页码:667 / 674
页数:8
相关论文
共 35 条
[1]  
AFIP, 2000, ARM FORC I PATH WEDN, V18, P4
[2]   Comparative efficacy assessment of pentamidine isethionate and diminazene aceturate in the chemotherapy of Trypanosoma brucei brucei infection in dogs [J].
Akpa, P. O. ;
Ezeokonkwo, R. C. ;
Eze, C. A. ;
Anene, B. M. .
VETERINARY PARASITOLOGY, 2008, 151 (2-4) :139-149
[3]   A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats [J].
Anene, BM ;
Ezeokonkwo, RC ;
Mmesirionye, TI ;
Tettey, JNA ;
Brock, JM ;
Barrett, MP ;
De Koning, HP .
PARASITOLOGY, 2006, 132 :127-133
[4]  
ANIKA SM, 1989, TROP MED PARASITOL, V40, P419
[5]  
Bagley R.S., 2004, TRATADO MED INTERNA, P638
[6]  
Boyt W.P., 1968, RHOD VET C RHOD, P33
[7]  
Collett MG, 2000, J S AFR VET ASSOC, V71, P180
[8]   Diminazene aceturate and imidocarb dipropionate in the control of Trypanosoma evansi infection in Rattus norvegicus experimentally infected [J].
da Silva, Aleksandro Schafer ;
Tochetto, Camila ;
Zanette, Regis Adriel ;
Pierezan, Felipe ;
Rissi, Daniel Ricardo ;
Santurio, Janio Morais ;
Monteiro, Silvia Gonzalez .
CIENCIA RURAL, 2008, 38 (05) :1357-1362
[9]   THE EFFECT OF TRYPANOCIDAL DRUG-TREATMENT ON THE HEMATOLOGICAL-CHANGES IN TRYPANOSOMA-BRUCEI-BRUCEI INFECTED SPLENECTOMIZED DOGS [J].
EGBENWIYI, TN ;
ANTIA, RE .
VETERINARY PARASITOLOGY, 1993, 50 (1-2) :23-33
[10]  
Fenner W.R., 2004, TRATADO MED INTERNA, P586