Rise of TRIM8: A Molecule of Duality

被引：24

作者：

Bhaduri, Utsa ^{[1
,2
,3
]}

Merla, Giuseppe ^{[1
]}

机构：

[1] Fdn IRCCS Casa Sollievo della Sofferenza, Div Med Genet, Viale Cappuccini, I-71013 Foggia, Italy

[2] Univ Trieste, Dept Life Sci, PhD Programme Mol Biomed, Trieste, Italy

[3] Univ Trieste, European Unions Horizon TRIM NET Innovat Training, Trieste, Italy

来源：

MOLECULAR THERAPY-NUCLEIC ACIDS | 2020年 / 22卷

基金：

欧盟地平线“2020”;

关键词：

cancer; E3 ubiquitin ligases; TRIM family; TRIM8;

D O I：

10.1016/j.omtn.2020.08.034

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The human tripartite motif containing protein 8 (TRIM8), a member of TRIM family proteins, is known to play a dual role as both tumor suppressor and oncogene, and to function at the crosstalk of cancer and innate immunity. In this review, in addition to accumulating recent corroborations that endorse this dual character of TRIM8, we appraise the game-changing capacity of TRIM8 under stress conditions against the backdrop of cell proliferation, apoptosis, and cancer, and also highlight the duality of TRIM8 in multiple contexts like cellular localization, stress-induced conditions, and E3 ubiquitin ligase activity. Finally, we discuss the emerging role of TRIM8 during bipolar spindle formation and mitotic progression, and its growing sphere of influence across multiple human cancers and pathologies, and suggest TRIM8-linked axes that can be modulated further for anti-cancer therapeutics development.

引用

页码：434 / 444

页数：11

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