Genotypic identification of sequential Candida albicans isolates from AIDS patients by polymerase chain reaction techniques

被引:31
作者
Barchiesi, F
DiFrancesco, LF
Compagnucci, P
Arzeni, D
Cirioni, O
Scalise, G
机构
[1] Università degli Studi di Ancona,Istituto di Malattie Infettive & Medicina Pubblica
[2] Ospedale Umberto I0,undefined
关键词
D O I
10.1007/BF02447925
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Random amplification of polymorphic DNA and inter-repeat polymerase chain reaction (IR-PCR) were compared with restriction fragment length polymorphism (RFLP) analysis as methods for DNA typing of Candida albicans. Forty-seven strains of Candida albicans isolated from the oral cavities of five AIDS patients undergoing fluconazole therapy were analyzed. There was an excellent correspondence between the DNA types obtained by both PCR-based techniques and by RFLP. With the exception of one patient who was infected with three DNA types of Candida albicans during a five-year observation period, the patients each harboured only one major strain, which became progressively less susceptible to fluconazole. Each DNA type was unique to a patient, The data suggest that these typing methods are suitable for investigating the epidemiology of oropharyngeal candidiasis in this patient group.
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收藏
页码:601 / 605
页数:5
相关论文
共 16 条
[1]   DNA SUBTYPES AND FLUCONAZOLE SUSCEPTIBILITIES OF CANDIDA-ALBICANS ISOLATES FROM THE ORAL CAVITIES OF PATIENTS WITH AIDS [J].
BARCHIESI, F ;
HOLLIS, RJ ;
MCGOUGH, DA ;
SCALISE, G ;
RINALDI, MG ;
PFALLER, MA .
CLINICAL INFECTIOUS DISEASES, 1995, 20 (03) :634-640
[2]  
BARTDELLABESSE E, 1993, J CLIN MICROBIOL, V31, P1933
[3]   Typing Candida albicans oral isolates from human immunodeficiency virus-infected patients by multilocus enzyme electrophoresis and DNA fingerprinting [J].
Boerlin, P ;
BoerlinPetzold, F ;
Goudet, J ;
Durussel, C ;
Pagani, JL ;
Chave, JP ;
Bille, J .
JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (05) :1235-1248
[4]   COMPARISON OF PCR FINGERPRINTING, BY RANDOM AMPLIFICATION OF POLYMORPHIC DNA, WITH OTHER MOLECULAR TYPING METHODS FOR CANDIDA-ALBICANS [J].
BOSTOCK, A ;
KHATTAK, MN ;
MATTHEWS, R ;
BURNIE, J .
JOURNAL OF GENERAL MICROBIOLOGY, 1993, 139 :2179-2184
[5]  
*BRIT SOC ANT CHEM, 1992, LANCET, V340, P648
[6]   ORAL CANDIDIASIS IN HIGH-RISK PATIENTS AS THE INITIAL MANIFESTATION OF THE ACQUIRED IMMUNODEFICIENCY SYNDROME [J].
KLEIN, RS ;
HARRIS, CA ;
SMALL, CB ;
MOLL, B ;
LESSER, M ;
FRIEDLAND, GH .
NEW ENGLAND JOURNAL OF MEDICINE, 1984, 311 (06) :354-358
[7]   GENOTYPIC IDENTIFICATION AND CHARACTERIZATION OF SPECIES AND STRAINS WITHIN THE GENUS CANDIDA BY USING RANDOM AMPLIFIED POLYMORPHIC DNA [J].
LEHMANN, PF ;
LIN, DM ;
LASKER, BA .
JOURNAL OF CLINICAL MICROBIOLOGY, 1992, 30 (12) :3249-3254
[8]  
*NAT COMM CLIN LAB, 1995, M27T NCCLS
[9]   VARIATIONS IN FLUCONAZOLE SUSCEPTIBILITY AND ELECTROPHORETIC KARYOTYPE AMONG ORAL ISOLATES OF CANDIDA-ALBICANS FROM PATIENTS WITH AIDS AND ORAL CANDIDIASIS [J].
PFALLER, MA ;
RHINECHALBERG, J ;
REDDING, SW ;
SMITH, J ;
FARINACCI, G ;
FOTHERGILL, AW ;
RINALDI, MG .
JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (01) :59-64
[10]  
PFALLER MA, 1994, CLIN INFECT DIS S1, V19, P8