Anxiety in Parkinson's disease: Abnormal resting activity and connectivity

被引：14
作者：
Criaud, Marion [3 ,4 ]
Kim, Jin-Hee [3 ,4 ]
Zurowski, Mateusz [4 ,6 ]
Lobaugh, Nancy [3 ,5 ]
Chavez, Sofia [3 ]
Houle, Sylvain [3 ]
Strafella, Antonio P. [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Toronto, Toronto Western Hosp, Morton & Gloria Shulman Movement Disorder Unit, UHN, Toronto, ON, Canada
[2] Univ Toronto, Toronto Western Hosp, EJ Safra Parkinson Dis Program, UHN, Toronto, ON, Canada
[3] Univ Toronto, Res Imaging Ctr, Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Toronto, ON, Canada
[4] Univ Toronto, Krembil Res Inst, Div Brain Imaging & Behav Syst Neurosci, UHN, Toronto, ON, Canada
[5] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada
[6] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
来源：
BRAIN RESEARCH | 2021年 / 1753卷
基金：
加拿大健康研究院;
关键词：
Parkinson's disease; Anxiety; Non-motor symptoms; Dopamine; Cognition; Behaviour; FUNCTIONAL CONNECTIVITY; NONMOTOR SYMPTOMS; BRAIN STRUCTURE; BASE-LINE; DEPRESSION; DOPAMINE; AMYGDALA; FLUCTUATIONS; DYSFUNCTION; PREVALENCE;
D O I：
10.1016/j.brainres.2020.147235
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Anxiety is a very common yet poorly understood symptom of Parkinson's disease. We investigated whether Parkinson's disease patients experiencing anxiety share neural mechanisms described in the general population with involvement of critical regions for the control of behaviour and movement. Thirty-nine patients with PD were recruited for this study, 20 with higher anxiety scores and 19 with lower anxiety scores. They all underwent a resting-state fMRI scan, while they were on medication. The amplitude of low-frequency fluctuation (ALFF) and seed-based connectivity were investigated to reveal the changes of the spontaneous activity and the interaction among different related regions. The results provided evidence that anxiety in Parkinson's disease is associated with the over-activation of the amygdala and impaired inter-relationship of regions involved in behavior (i.e. medial prefrontal cortex, insula) and motor control (i.e. basal ganglia).
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页数：7
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