Anxiety in Parkinson's disease: Abnormal resting activity and connectivity

被引：16
作者：
Criaud, Marion [3 ,4 ]
Kim, Jin-Hee [3 ,4 ]
Zurowski, Mateusz [4 ,6 ]
Lobaugh, Nancy [3 ,5 ]
Chavez, Sofia [3 ]
Houle, Sylvain [3 ]
Strafella, Antonio P. [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Toronto, Toronto Western Hosp, Morton & Gloria Shulman Movement Disorder Unit, UHN, Toronto, ON, Canada
[2] Univ Toronto, Toronto Western Hosp, EJ Safra Parkinson Dis Program, UHN, Toronto, ON, Canada
[3] Univ Toronto, Res Imaging Ctr, Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Toronto, ON, Canada
[4] Univ Toronto, Krembil Res Inst, Div Brain Imaging & Behav Syst Neurosci, UHN, Toronto, ON, Canada
[5] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada
[6] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
来源：
BRAIN RESEARCH | 2021年 / 1753卷
基金：
加拿大健康研究院;
关键词：
Parkinson's disease; Anxiety; Non-motor symptoms; Dopamine; Cognition; Behaviour; FUNCTIONAL CONNECTIVITY; NONMOTOR SYMPTOMS; BRAIN STRUCTURE; BASE-LINE; DEPRESSION; DOPAMINE; AMYGDALA; FLUCTUATIONS; DYSFUNCTION; PREVALENCE;
D O I：
10.1016/j.brainres.2020.147235
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Anxiety is a very common yet poorly understood symptom of Parkinson's disease. We investigated whether Parkinson's disease patients experiencing anxiety share neural mechanisms described in the general population with involvement of critical regions for the control of behaviour and movement. Thirty-nine patients with PD were recruited for this study, 20 with higher anxiety scores and 19 with lower anxiety scores. They all underwent a resting-state fMRI scan, while they were on medication. The amplitude of low-frequency fluctuation (ALFF) and seed-based connectivity were investigated to reveal the changes of the spontaneous activity and the interaction among different related regions. The results provided evidence that anxiety in Parkinson's disease is associated with the over-activation of the amygdala and impaired inter-relationship of regions involved in behavior (i.e. medial prefrontal cortex, insula) and motor control (i.e. basal ganglia).
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页数：7
相关论文
共 58 条
[1]   Review of EEG, ERP, and Brain Connectivity Estimators as Predictive Biomarkers of Social Anxiety Disorder [J].
Al-Ezzi, Abdulhakim ;
Kamel, Nidal ;
Faye, Ibrahima ;
Gunaseli, Esther .
FRONTIERS IN PSYCHOLOGY, 2020, 11
[2]  
[Anonymous], 2010, The Corsini Encyclopedia of Psychology. vol, DOI [DOI 10.1002/9780470479216.CORPSY0943, 10.1002/9780470479216.corpsy0943]
[3]  
Association AP, 2013, DIAGN STAT MAN MENT, V5th, DOI DOI 10.1176/APPI.BOOKS.9780890425596
[4]   A component based noise correction method (CompCor) for BOLD and perfusion based fMRI [J].
Behzadi, Yashar ;
Restom, Khaled ;
Liau, Joy ;
Liu, Thomas T. .
NEUROIMAGE, 2007, 37 (01) :90-101
[5]   Stanley Fahn Lecture 2005:: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered [J].
Braak, Heiko ;
Bohl, Juergen R. ;
Muller, Christian M. ;
Rub, Udo ;
de Vos, Rob A. I. ;
Del Tredici, Kelly .
MOVEMENT DISORDERS, 2006, 21 (12) :2042-2051
[6]   Prevalence of anxiety in Parkinson's disease: A systematic review and meta-analysis [J].
Broen, Martijn P. G. ;
Narayen, Nadia E. ;
Kuijf, Mark L. ;
Dissanayaka, Nadeeka N. W. ;
Leentjens, Albert F. G. .
MOVEMENT DISORDERS, 2016, 31 (08) :1125-1133
[7]   Functional connectivity of the insula in the resting brain [J].
Cauda, Franco ;
D'Agata, Federico ;
Sacco, Katiuscia ;
Duca, Sergio ;
Geminiani, Giuliano ;
Vercelli, Alessandro .
NEUROIMAGE, 2011, 55 (01) :8-23
[8]   Mild affective symptoms in de novo Parkinson's disease patients: relationship with dopaminergic dysfunction [J].
Ceravolo, R. ;
Frosini, D. ;
Poletti, M. ;
Kiferle, L. ;
Pagni, C. ;
Mazzucchi, S. ;
Volterrani, D. ;
Bonuccelli, U. .
EUROPEAN JOURNAL OF NEUROLOGY, 2013, 20 (03) :480-485
[9]   Anticorrelations in resting state networks without global signal regression [J].
Chai, Xiaoqian J. ;
Castanon, Alfonso Nieto ;
Oenguer, Dost ;
Whitfield-Gabrieli, Susan .
NEUROIMAGE, 2012, 59 (02) :1420-1428
[10]   Uncovering the role of the insula in non-motor symptoms of Parkinson's disease [J].
Christopher, Leigh ;
Koshimori, Yuko ;
Lang, Anthony E. ;
Criaud, Marion ;
Strafella, Antonio P. .
BRAIN, 2014, 137 :2143-2154
123456