Electron-irradiation-induced decomposition of sulfonamides

被引:6
作者
Liu Zhitao
Zhang Huayi [1 ]
Shao Bing
Zhao Rong
机构
[1] Tsing Hua Univ, Dept Engn Phys, Beijing 100084, Peoples R China
[2] Beijing Ctr Dis Prevent & Control, Inst Nutr & Food Hyg, Beijing, Peoples R China
关键词
suffonamides; electron beam irradiation; decomposition;
D O I
10.1016/j.nimb.2006.09.002
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
The effect of electron irradiation on sulfanilamide (SA) and sulfadimethoxine (SDM) solutions has been studied at various irradiation doses and various original concentrations. Upon irradiation at 8 kGy, the concentration of 110 mg/kg SDM decreased by 94%, while 130 mg/kg SA decreased by 99.2%. When exposed to the same dose, The radiolytic products were identified by ultra performance liquid chromatography electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS) and the oxidation pathways were proposed. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:285 / 289
页数:5
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