The many functions of SMC proteins in chromosome dynamics

被引：132
作者：
Jessberger, R [1 ]
机构：
[1] Mt Sinai Sch Med, Carl C Icahn Inst Gene Therapy & Mol Med, New York, NY 10029 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 10期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm930
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Members of the structural maintenance of chromosomes (SMC) family share a characteristic design and configuration of protein domains that provides the molecular basis for the various functions of this family in chromosome dynamics. SMC proteins have a role in chromosome condensation, sister-chromatid cohesion, DNA repair and recombination, and gene dosage compensation, and they function in somatic and meiotic cells. As more is learned about how their unique design affects their function, a picture of a dynamic and varied protein family is emerging.
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收藏
页码：767 / 778
页数：12
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