Contact sensitivity in patients with leg ulcerations - A North American study

被引:77
作者
Saap, L
Fahim, S
Arsenault, E
Pratt, M
Pierscianowski, T
Falanga, V
Pedvis-Leftick, A
机构
[1] Boston Univ, Roger Williams Med Ctr, Dept Dermatol & Skin Surg, Providence, RI 02908 USA
[2] Univ Ottawa, Dept Dermatol, Ottawa, ON, Canada
[3] Boston Univ, Dept Dermatol, Boston, MA 02215 USA
[4] Boston Univ, Dept Biochem, Boston, MA 02215 USA
关键词
D O I
10.1001/archderm.140.10.1241
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Objectives: (1) To determine the prevalence of allergen sensitivity in patients with past or present leg ulcers in 2 North American study centers vs European study findings and the North American Contact Dermatitis Group (NACDG) database and (2) to delineate a standard battery of allergens for patch testing in North American patients that is representative of the newer dressings and wound care products. Design: Fifty-four patients, with or without dermatitis, were prospectively entered in the study. The patients were patch tested to the NACDG standard series and a comprehensive supplemental series of 52 allergens. Setting: Wound healing clinics at Boston University Roger Williams Medical Center and University of Ottawa. Results: Sixty-three percent (n=34) of patients had 1 or multiple positive patch test results, and 37% (n=20) had no positive patch test result. The most common allergens were Myroxylon pereirae (balsam of Peru) (30% [16/54]), bacitracin (24% [13/54]), fragrance mix (20% [11/54]), wood tar mix (20% [11/54]), propylene glycol (14% [7/52]), neomycin sulfate (13% [7/54]), benzalkonium chloride (13% [7/54]), carba mix (11% [6/54]), nickel sulfate (11% [6/54]), and control gel hydrocolloid (11% [6/54]). Conclusions: Comparable to European study findings, there is a high incidence of positive patch test results in patients with past or present leg ulcerations. The incidences of the most common allergens in our patient population were higher than those seen in the NACDG, except for nickel. Using a modified leg ulcer series along with the standard NACDG series is important in evaluating patients with leg ulcers.
引用
收藏
页码:1241 / 1246
页数:6
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