Dietary Intervention with AHP, a Functional Formula Diet, Improves Both Serum and Hepatic Lipids Profile in Dyslipidemia Mice

被引:18
作者
Luo, Yangchao [1 ]
Chen, Gang [2 ]
Li, Bo [1 ]
Ji, Baoping [1 ]
Xiao, Zhenlei [1 ]
Yi, Guo [3 ]
Tian, Fang [1 ]
机构
[1] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100094, Peoples R China
[2] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang, Peoples R China
[3] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA
关键词
antioxidant status; dyslipidemia; fatty liver; formula diet; lipids profile; AURICULARIA-AURICULA; HAWTHORN; RATS; CHOLESTEROL; HYPERCHOLESTEROLEMIA; STEATOSIS; DISEASE; FRUIT; EAR;
D O I
10.1111/j.1750-3841.2009.01241.x
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Aurricularia aurricula, hawthorn (Crataegus pinnatifida), and Pueraria radix are well known for both traditional food and folk medicine. Each of the above 3 plants possesses a distinct pathway contributing to treat dyslipidemia. To develop a health-promoting diet against dyslipidemia, the polysaccharides from A. aurricula, polyphenol from hawthorn, and P. radix were combined to postulate as a functional formula diet (AHP) in the present study and its pharmaceutical effects and underlying mechanisms were elucidated in vivo. The dyslipidemia model associated with fatty liver was induced by cholesterol-enriched diet (CED) for up to 12 wk in male ICR mice. Mice were randomly divided into 5 groups, that is, regular diet (RD), CED, Xuezhikang treatment (positive control group, PG), low and high (150 or 450 mg/kg/d) of AHP treatment groups. Compared with the CED group, AHP groups maintained lipid profiles through lowering serum total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C), inhibiting the accumulation of hepatic TC and triglyceride (TG). AHP could also improve both serum and hepatic biochemical activity profiles including antioxidant status, serum nitric oxide (NO), and hepatic 3-hydroxy3- methylglutary CoA (HMG-CoA) reductase levels. Hepatic histopathological examinations showed markedly decreased fatty deposits in the liver of AHP-treated mice, illustrating the ability to reverse a condition of fatty liver. Our study indicated that this functional formula diet would be a potent alternative as a health-promoting diet, simultaneously targeting on the complexity and redundancy of dyslipidemia.
引用
收藏
页码:H189 / H195
页数:7
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