Fluorinated trimethyllysine as a 19F NMR probe for trimethyllysine hydroxylase catalysis

被引：5

作者：

Reddy, Y. Vijayendar ^{[1
]}

Al Temimi, Abbas H. K. ^{[1
]}

Mecinovic, Jasmin ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 06期

关键词：

GAMMA-BUTYROBETAINE HYDROXYLASE; CARNITINE BIOSYNTHESIS; 3-HYDROXY-N6-TRIMETHYL-LYSINE; N6-TRIMETHYL-LYSINE;

D O I：

10.1039/c6ob02683d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of Ne-trimethyllysine in the first step of carnitine biosynthesis in humans. Studies on TMLH have been hampered by the lack of established chemical methods. We report that an Ne-trimethyllysine analogue that contains the fluoromethyl group can be used as a H-1 and F-19 NMR probe for studies on TMLH catalysis.

引用

页码：1350 / 1354

页数：5