A simple highly selective and sensitive hydroquinone-based two-photon fluorescent probe for imaging peroxynitrite in live cells

被引：78

作者：

Zhu, Baocun ^{[1
]}

Wang, Zuokai ^{[1
]}

Zhao, Ziyang ^{[1
]}

Shu, Wei ^{[1
]}

Zhang, Meng ^{[1
]}

Wu, Liu ^{[1
]}

Liu, Caiyun ^{[1
]}

Duan, Qingxia ^{[1
]}

Jia, Pan ^{[1
]}

机构：

[1] Univ Jinan, Shandong Prov Engn Technol Res Ctr Ecol Carbon Si, Sch Resources & Environm, Jinan 250022, Shandong, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2018年 / 262卷

基金：

中国国家自然科学基金;

关键词：

Fluorescent probe; Peroxynitrite (ONOO-); Hydroquinone; Hydroxynaphthalimide; Two-photon bioimaging; DRUG-INDUCED HEPATOTOXICITY; HYDROGEN-PEROXIDE; ENDOGENOUS PEROXYNITRITE; FAST-RESPONSE; MITOCHONDRIA; VISUALIZATION;

D O I：

10.1016/j.snb.2018.01.203

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Exploiting specific and sensitive techniques for tracking peroxynitrite (ONOO-) in the biological systems is of great significance to understand its diverse pathophysiology. Herein, we have constructed a simple, 4-hydroxynaphthalimide-derived two-photon fluorescent probe TPHQ for imaging ONOO- in live cells. Probe TPHQ with the recognition receptor of hydroquinone moiety exhibited excellent selectivity towards ONOO- over various bio-related analytes including H2O2 and OCl-. Additionally, probe TPHQ could rapidly monitor ONOO- with high sensitivity (DL = 16 nM). With probe TPHQ the fluctuations of ONOO- levels in live cells were successfully tracked by the one-photon and two-photon fluorescence microscopy. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：380 / 385

页数：6

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