A simple highly selective and sensitive hydroquinone-based two-photon fluorescent probe for imaging peroxynitrite in live cells

被引：78
作者：
Zhu, Baocun [1 ]
Wang, Zuokai [1 ]
Zhao, Ziyang [1 ]
Shu, Wei [1 ]
Zhang, Meng [1 ]
Wu, Liu [1 ]
Liu, Caiyun [1 ]
Duan, Qingxia [1 ]
Jia, Pan [1 ]
机构：
[1] Univ Jinan, Shandong Prov Engn Technol Res Ctr Ecol Carbon Si, Sch Resources & Environm, Jinan 250022, Shandong, Peoples R China
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2018年 / 262卷
基金：
中国国家自然科学基金;
关键词：
Fluorescent probe; Peroxynitrite (ONOO-); Hydroquinone; Hydroxynaphthalimide; Two-photon bioimaging; DRUG-INDUCED HEPATOTOXICITY; HYDROGEN-PEROXIDE; ENDOGENOUS PEROXYNITRITE; FAST-RESPONSE; MITOCHONDRIA; VISUALIZATION;
D O I：
10.1016/j.snb.2018.01.203
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Exploiting specific and sensitive techniques for tracking peroxynitrite (ONOO-) in the biological systems is of great significance to understand its diverse pathophysiology. Herein, we have constructed a simple, 4-hydroxynaphthalimide-derived two-photon fluorescent probe TPHQ for imaging ONOO- in live cells. Probe TPHQ with the recognition receptor of hydroquinone moiety exhibited excellent selectivity towards ONOO- over various bio-related analytes including H2O2 and OCl-. Additionally, probe TPHQ could rapidly monitor ONOO- with high sensitivity (DL = 16 nM). With probe TPHQ the fluctuations of ONOO- levels in live cells were successfully tracked by the one-photon and two-photon fluorescence microscopy. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：380 / 385
页数：6
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