The biogenesis of multivesicular endosomes

被引：581
作者：
Gruenberg, J
Stenmark, H
机构：
[1] Univ Geneva, Dept Biochem, CH-1211 Geneva 4, Switzerland
[2] Norwegian Radium Hosp, Inst Canc Res, Dept Biochem, N-0310 Oslo, Norway
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 04期
关键词：
D O I：
10.1038/nrm1360
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recent progress has been made in our understanding of the molecular mechanisms that regulate the biogenesis of multivesicular transport intermediates in the degradation pathway that leads to lysosomes. Here, we discuss recent work that uncovers some of the mechanisms that cause both membrane invagination within these newly forming intermediates and the detachment of these intermediates from early endosomal membranes.
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页码：317 / 323
页数：7
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