Vitamin D Status of Mice Deficient in Scavenger Receptor Class B Type 1, Cluster Determinant 36 and ATP-Binding Cassette Proteins G5/G8

被引:16
作者
Kiourtzidis, Mikis [1 ]
Kuehn, Julia [1 ]
Brandsch, Corinna [1 ]
Stangl, Gabriele I. [1 ,2 ]
机构
[1] Martin Luther Univ Halle Wittenberg, Inst Agr & Nutr Sci, Von Danckelmann Pl 2, D-06120 Halle, Saale, Germany
[2] Halle Jena Leipzig, Competence Cluster Cardiovasc Hlth & Nutr nutriCA, Deutsch Pl 5E, D-04103 Leipzig, Germany
关键词
ATP-binding cassette transporters G5; G8; cluster determinant 36; scavenger receptor class B type 1; vitamin D; mice; FATTY-ACID TRANSPORT; PLASMA-LIPID LEVELS; SR-BI; TARGETED MUTATION; CHOLESTEROL; CD36; SECRETION; ABCG8; POLYMORPHISMS; ASSOCIATION;
D O I
10.3390/nu12082169
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Classical lipid transporters are suggested to modulate cellular vitamin D uptake. This study investigated the vitamin D levels in serum and tissues of mice deficient in SR-B1 (Srb1(-/-)), CD36 (Cd36(-/-)) and ABC-G5/G8 (Abcg5/g8(-/-)) and compared them with corresponding wild-type (WT) mice. All mice received triple-deuterated vitamin D-3(vitamin D-3-d(3)) for six weeks. All knockout mice vs. WT mice showed specific alterations in their vitamin D concentrations. Srb1(-/-)mice had higher levels of vitamin D-3-d(3)in the serum, adipose tissue, kidney and heart, whereas liver levels of vitamin D-3-d(3)remained unaffected. Additionally, Srb1(-/-)mice had lower levels of deuterated 25-hydroxyvitamin D-3(25(OH)D-3-d(3)) in the serum, liver and kidney compared to WT mice. In contrast, Cd36(-/-)and WT mice did not differ in the serum and tissue levels of vitamin D-3-d(3), but Cd36(-/-)vs. WT mice were characterized by lower levels of 25(OH)D-3-d(3)in the serum, liver and kidney. Finally, Abcg5/g8(-/-)mice tended to have higher levels of vitamin D-3-d(3)in the serum and liver. Major alterations in Abcg5/g8(-/-)mice were notably higher levels of 25(OH)D-3-d(3)in the serum and kidney, accompanied by a higher hepatic mRNA abundance ofCyp27a1hydroxylase. To conclude, the current data emphasize the significant role of lipid transporters in the uptake, tissue distribution and activation of vitamin D.
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页码:1 / 14
页数:14
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