Varitatin A, a Highly Modified Fatty Acid Amide from Penicillium variabile Cultured with a DNA Methyltransferase Inhibitor

被引：38

作者：

He, Xueqian ^{[1
]}

Zhang, Zhenzhen ^{[1
]}

Chen, Yinghan ^{[1
]}

Che, Qian ^{[1
]}

Zhu, Tianjiao ^{[1
]}

Gu, Qianqun ^{[1
]}

Li, Dehai ^{[1
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2015年 / 78卷 / 11期

基金：

国家高技术研究发展计划(863计划);

关键词：

MARINE NATURAL-PRODUCTS; ABSOLUTE-CONFIGURATION; BICYCLIC HEMIACETALS; FUNGUS; SCYPHOSTATIN;

D O I：

10.1021/acs.jnatprod.5b00742

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new, highly modified fatty acid amide, varitatin A (1), was isolated from the fungus Penicillium variabile HXQ-H-1 cultivated with the DNA methyltransferase inhibitor 5-azacytidine. The structure including the absolute configuration of 1 was established by analysis of NMR and MS data, together with chemical degradation and Mosher's method based on MPA esters. Compound 1 showed cytotoxicity against HCT-116 cells with an IC50 value of 2.8 mu M and also inhibited the effects of protein tyrosine kinases.

引用

收藏

页码：2841 / 2845

页数：5

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