Squamous cell vulvar carcinoma associated with Fanconi's anemia: a case report

被引：20
作者：
Carvalho, JP
Dias, MLN
Carvalho, FM
Diz, MDE
Petito, JW
机构：
[1] Univ Sao Paulo, Sch Med, Dept Gynecol, Sao Paulo, Brazil
[2] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil
[3] Univ Sao Paulo, Sch Med, Clin Oncol Serv, Sao Paulo, Brazil
[4] Univ Sao Paulo, Sch Med, Radiotherapy Serv, Sao Paulo, Brazil
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | 2002年 / 12卷 / 02期
关键词：
Fanconi's anemia; squamous cell carcinoma; vulvar neoplasms;
D O I：
10.1046/j.1525-1438.2002.01090.x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Fanconi's anemia (FA) is a rare autosomal recessive syndrome associated with a strong predisposition to cancer, particularly squamous cell carcinoma (SCC) of various organs. A few cases of lower genital tract neoplasia have been described. We present a 14-year-old black girl with an advanced squamous cell vulvar carcinoma treated with cisplatin chemotherapy plus radiation therapy. The patient died because of fungal sepsis. Polymerase chain reaction (PCR) was positive to human papillomavirus (HPV)-16. Vulvar carcinoma is a very rare condition in teenagers, but the association of Fanconi's anemia and SCC of many sites is common. Vulvar carcinoma when associated with Fanconi's anemia is a great treatment challenge.
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收藏
页码：220 / 222
页数：3
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