Localization and RNA Binding of Mitochondrial Aminoacyl tRNA Synthetases

被引:12
作者
Garin, Shahar [1 ]
Levi, Ofri [1 ]
Cohen, Bar [1 ]
Golani-Armon, Adi [1 ]
Arava, Yoav S. [1 ]
机构
[1] Technion Israel Inst Technol, Fac Biol, IL-32000 Haifa, Israel
基金
以色列科学基金会;
关键词
aminoacyl tRNA synthetase; mitochondria; tRNA; mitochondria import; mitochondria targeting signal; RNA recognition; translation; MESSENGER-RNA; TRANSLATIONAL CONTROL; PROTEIN-SYNTHESIS; GENE ENCODES; SACCHAROMYCES-CEREVISIAE; SPLICING FACTOR; ATP SYNTHASE; N-TERMINI; YEAST; MECHANISMS;
D O I
10.3390/genes11101185
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Mitochondria contain a complete translation machinery that is used to translate its internally transcribed mRNAs. This machinery uses a distinct set of tRNAs that are charged with cognate amino acids inside the organelle. Interestingly, charging is executed by aminoacyl tRNA synthetases (aaRS) that are encoded by the nuclear genome, translated in the cytosol, and need to be imported into the mitochondria. Here, we review import mechanisms of these enzymes with emphasis on those that are localized to both mitochondria and cytosol. Furthermore, we describe RNA recognition features of these enzymes and their interaction with tRNA and non-tRNA molecules. The dual localization of mitochondria-destined aaRSs and their association with various RNA types impose diverse impacts on cellular physiology. Yet, the breadth and significance of these functions are not fully resolved. We highlight here possibilities for future explorations.
引用
收藏
页码:1 / 20
页数:20
相关论文
共 157 条
  • [91] Conserved mRNA-binding proteomes in eukaryotic organisms
    Matia-Gonzalez, Ana M.
    Laing, Emma E.
    Gerber, Andre P.
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2015, 22 (12) : 1027 - 1033
  • [92] Mitochondria: More than just a powerhouse
    McBride, Heidi M.
    Neuspiel, Margaret
    Wasiak, Sylwia
    [J]. CURRENT BIOLOGY, 2006, 16 (14) : R551 - R560
  • [93] CHANGING THE IDENTITY OF A TRANSFER-RNA BY INTRODUCING A G-U WOBBLE PAIR NEAR THE 3' ACCEPTOR END
    MCCLAIN, WH
    FOSS, K
    [J]. SCIENCE, 1988, 240 (4853) : 793 - 796
  • [94] Differential targeting of VDAC3 mRNA isoforms influences mitochondria morphology
    Michaud, Morgane
    Ubrig, Elodie
    Filleur, Sophie
    Erhardt, Mathieu
    Ephritikhine, Genevieve
    Marechal-Drouard, Laurence
    Duchene, Anne-Marie
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (24) : 8991 - 8996
  • [95] The same Arabidopsis gene encodes both cytosolic and mitochondrial alanyl-tRNA synthetases
    Mireau, H
    Lancelin, D
    Small, ID
    [J]. PLANT CELL, 1996, 8 (06) : 1027 - 1039
  • [96] Function of the Neurospora crassa mitochondrial tyrosyl-tRNA synthetase in RNA splicing.: Role of the idiosyncratic N-terminal extension and different modes of interaction with different group I introns
    Mohr, G
    Rennard, R
    Cherniack, AD
    Stryker, J
    Lambowitz, AM
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2001, 307 (01) : 75 - 92
  • [97] Non-canonical translation initiation in yeast generates a cryptic pool of mitochondrial proteins
    Monteuuis, Geoffray
    Miscicka, Anna
    Swirski, Michal
    Zenad, Lounis
    Niemitalo, Olli
    Wrobel, Lidia
    Alam, Jahangir
    Chacinska, Agnieszka
    Kastaniotis, Alexander J.
    Kufel, Joanna
    [J]. NUCLEIC ACIDS RESEARCH, 2019, 47 (11) : 5777 - 5791
  • [98] Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale
    Morgenstern, Marcel
    Stiller, Sebastian B.
    Luebbert, Philipp
    Peikert, Christian D.
    Dannenmaier, Stefan
    Drepper, Friedel
    Weill, Uri
    Hoess, Philipp
    Feuerstein, Reinhild
    Gebert, Michael
    Bohnert, Maria
    van der Laan, Martin
    Schuldiner, Maya
    Schuetze, Conny
    Oeljeklaus, Silke
    Pfanner, Nikolaus
    Wiedemann, Nils
    Warscheid, Bettina
    [J]. CELL REPORTS, 2017, 19 (13): : 2836 - 2852
  • [99] Processing of mitochondrial presequences
    Mossmann, Dirk
    Meisinger, Chris
    Voegtle, F. -Nora
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2012, 1819 (9-10): : 1098 - 1106
  • [100] MiSynPat: An integrated knowledge base linking clinical, genetic, and structural data for disease-causingmutations in human mitochondrial aminoacyl-tRNA synthetases
    Moulinier, Luc
    Ripp, Raymond
    Castillo, Gaston
    Poch, Olivier
    Sissler, Marie
    [J]. HUMAN MUTATION, 2017, 38 (10) : 1316 - 1324