Getting Pumped about Heart Failure

被引：6

作者：

Mann, Douglas L. ^{[1
]}

机构：

[1] Washington Univ Sch Med, Div Cardiol, Dept Med, Ctr Cardiovasc Res, St Louis, MO 63110 USA

来源：

CELL METABOLISM | 2014年 / 19卷 / 06期

关键词：

DISEASE;

D O I：

10.1016/j.cmet.2014.05.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Heart failure is a clinical syndrome caused by dysregulated calcium handling and abnormal cardiac pumping capacity. Wahlquist et al. (2014) show that upregulation of microRNA-25 impairs calcium handling leading to pump dysfunction and that targeting microRNA-25 using antisense oligonucleotides reverses pump dysfunction and improves survival in mice with heart failure.

引用

页码：896 / 897

页数：2

共 6 条

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