Biocompatibility and mechanical properties of pigeon bone waste extracted natural nano-hydroxyapatite for bone tissue engineering

被引：67

作者：

Sharifianjazi, Fariborz ^{[1
]}

Esmaeilkhanian, Amirhossein ^{[1
]}

Moradi, Mostafa ^{[2
]}

Pakseresht, Amirhosein ^{[1
,3
]}

Asl, Mehdi Shahedi ^{[4
]}

Karimi-Maleh, Hassan ^{[5
,6
,9
]}

Jang, Ho Won ^{[7
]}

Shokouhimehr, Mohammadreza ^{[7
]}

Varma, Rajender S. ^{[8
]}

机构：

[1] Amirkabir Univ Technol, Dept Mat & Met Engn, Tehran, Iran

[2] Sharif Univ Technol, Dept Mat Sci & Engn, Tehran, Iran

[3] Alexander Dubcek Univ Trencin, Ctr Funct & Surface Funct Glass, Coating Dept, Trencin 91150, Slovakia

[4] Univ New Brunswick, Marine Addit Mfg Ctr Excellence MAMCE, Fredericton, NB E3B 5A1, Canada

[5] Univ Elect Sci & Technol China, Sch Resources & Environm, Xiyuan Ave,POB 611731, Chengdu, Peoples R China

[6] Univ Johannesburg, Dept Chem Sci, Doornfontein Campus,POB 17011, ZA-2028 Johannesburg, South Africa

[7] Seoul Natl Univ, Res Inst Adv Mat, Dept Mat Sci & Engn, Seoul 08826, South Korea

[8] Palacky Univ, Reg Ctr Adv Technol & Mat, Slechtitelu 27, Olomouc 78371, Czech Republic

[9] Quchan Univ Technol, Dept Chem Engn, Quchan, Iran

来源：

MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS | 2021年 / 264卷

基金：

新加坡国家研究基金会;

关键词：

Biocompatibility; Bone; Bio-waste materials; Tissue engineering; Compressive strength; Nano-hydroxyapatite; Nanomaterials; BIOACTIVE GLASS; MECHANOCHEMICAL SYNTHESIS; CUTTLEFISH BONE; NANOCOMPOSITE; ADSORPTION; SCAFFOLD; METALS;

D O I：

10.1016/j.mseb.2020.114950

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

One of the common bioactive materials used for clinical and biomedical applications is hydroxyapatite (HAp). Bio-waste materials are one of the major natural sources for the preparation of this bio-ceramic powder. Herein, naturally derived nano-HAp was prepared using the ball milling process after annealing of waste pigeon bones at 850 degrees C followed by cold-pressing the nanoparticles and re-sintering at 850, 950, 1050, and 1150 degrees C. The ball-milled pigeon-derived nano-hydroxyapatite (PHA) had an average particle size in the range of 50-250 nm and the Ca/P ratio of the sample sintered at 1050 degrees C was 1.7. Moreover, the hardness and compressive strength of sintered nano-HAp were improved to 47.57 MPa and 3.7 GPa, respectively by increasing the sintering temperature. Furthermore, alkaline phosphatase analysis and MTT assay of PHA indicated significant enhancement in the activity and proliferation of osteoblast cells during the culturing period in comparison to synthetic HAp.

引用

页数：7

共 58 条

[1] Bioactivity and biocompatibility of hydroxyapatite-based bioceramic coatings on zirconium by plasma electrolytic oxidation [J].