Angiogenesis and anti-angiogenesis in hepatocellular carcinoma

被引：80
作者：
Ribatti, Domenico
Vacca, Angelo
Nico, Beatrice
Sansonno, Domenico
Dammacco, Franco
机构：
[1] Univ Bari, Sch Med, Dept Human Anat & Histol, I-70124 Bari, Italy
[2] Univ Bari, Sch Med, Dept Internal Med & Clin Oncol, Bari, Italy
来源：
CANCER TREATMENT REVIEWS | 2006年 / 32卷 / 06期
关键词：
angiogenesis; anti-angiogenesis; hepatocellular carcinoma; tumor progression;
D O I：
10.1016/j.ctrv.2006.06.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Experimental and clinical data indicate that in human hepatocellular carcinoma (HCC) tumor progression is associated with angiogenesis and that an increase in microvascular density is associated with a poor prognosis. This review summarizes the literature concerning the relationship between angiogenesis and progression in HCC. It is becoming increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, anti-angiogenic tumor therapy has gained much interest in preclinical and clinical assessments. The recent applications of anti-angiogenic agents which interfere or block HCC progression are reviewed. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：437 / 444
页数：8
相关论文
共 89 条
[1]  
AZNAVOORIAN S, 1993, CANCER-AM CANCER SOC, V71, P1368, DOI 10.1002/1097-0142(19930215)71:4<1368::AID-CNCR2820710432>3.0.CO
[2]  
2-L
[3]   Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12 [J].
Barajas, M ;
Mazzolini, G ;
Genové, G ;
Bilbao, R ;
Narvaiza, I ;
Schmitz, V ;
Sangro, B ;
Melero, I ;
Qian, C ;
Prieto, J .
HEPATOLOGY, 2001, 33 (01) :52-61
[4]   Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis [J].
Bergers, G ;
Brekken, R ;
McMahon, G ;
Vu, TH ;
Itoh, T ;
Tamaki, K ;
Tanzawa, K ;
Thorpe, P ;
Itohara, S ;
Werb, Z ;
Hanahan, D .
NATURE CELL BIOLOGY, 2000, 2 (10) :737-744
[5]   The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies [J].
Bingle, L ;
Brown, NJ ;
Lewis, CE .
JOURNAL OF PATHOLOGY, 2002, 196 (03) :254-265
[6]   INHIBITION OF CELL MOTILITY BY INTERFERON [J].
BROUTYBOYE, D ;
ZETTER, BR .
SCIENCE, 1980, 208 (4443) :516-518
[7]  
Bu W, 1998, HEPATO-GASTROENTEROL, V45, P1056
[8]   ANGPTL3 stimulates endothelial cell adhesion and migration via integrin αvβ3 and induces blood vessel formation in vivo [J].
Camenisch, G ;
Pisabarro, MT ;
Sherman, D ;
Kowalski, J ;
Nagel, M ;
Hass, P ;
Xie, MH ;
Gurney, A ;
Bodary, S ;
Liang, XH ;
Clark, K ;
Beresini, M ;
Ferrara, N ;
Gerber, HP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (19) :17281-17290
[9]   Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery [J].
Chao, Y ;
Li, CP ;
Chau, GY ;
Chen, CP ;
King, KL ;
Lui, WY ;
Yen, SH ;
Chang, FY ;
Chan, WK ;
Lee, SD .
ANNALS OF SURGICAL ONCOLOGY, 2003, 10 (04) :355-362
[10]   Antiangiogenic gene therapy for cancer via systemic administration of adenoviral vectors expressing secretable endostatin [J].
Chen, CT ;
Lin, J ;
Li, Q ;
Phipps, SS ;
Jakubczak, JL ;
Stewart, DA ;
Skripchenko, Y ;
Forry-Schaudies, S ;
Wood, J ;
Schnell, C ;
Hallenbeck, PL .
HUMAN GENE THERAPY, 2000, 11 (14) :1983-1996
123456789