Synthesis and antiviral assays of some benzimidazole nucleosides and acyclonucleosides

被引：21
作者：
Garuti, L
Roberti, M
Gentilomi, G
机构：
[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy
[2] Univ Bologna, Div Microbiol, Dept Clin & Expt Med, I-40138 Bologna, Italy
来源：
FARMACO | 2001年 / 56卷 / 11期
关键词：
benzimidazoles; synthesis; nucleosides; acyclonucleosides; antiviral assays;
D O I：
10.1016/S0014-827X(01)01164-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Some benzimidazole nucleosides and acyclonucleosides were synthesized and tested in vitro as antiviral agents. None of them showed significant activity. Replacement of the benzenesulphonyl group at N-1 with the ribofuranosyl moiety or with the acyclovir side-chain was deleterious. (C) 2001 Elsevier Science S.A. All rights reserved.
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收藏
页码：815 / 819
页数：5
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