RNA Interference in Cancer: Targeting the Anti-Apoptotic Protein c-FLIP for Drug Discovery

被引：15
|
作者：
Day, Travis W. [1 ]
Safa, Ahmad R. [1 ]
机构：
[1] Indiana Univ, Sch Med, Dept Pharmacol & Toxicol, Simon Canc Ctr, Indianapolis, IN 46202 USA
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 06期
关键词：
RNA interference; c-FLIP; apoptosis; apoptotic pathways; drug discovery; cancer; caspases; TRAIL-INDUCED APOPTOSIS; NF-KAPPA-B; CHEMOTHERAPY-INDUCED APOPTOSIS; FAS-MEDIATED APOPTOSIS; INHIBITORY PROTEIN; CELL-DEATH; PROSTATE-CANCER; CHEMICAL-MODIFICATION; DOWN-REGULATION; IN-VIVO;
D O I：
10.2174/138955709788452748
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The silencing of genes by RNA interference (RNAi) has identified proteins involved in the resistance of cancers to chemotherapeutic drugs. Resistance is associated with defects in the apoptotic signaling pathways. In this article, we examine using RNAi to target the anti-apoptotic protein cellular FLICE-like inhibitory protein (c-FLIP) for drug development.
引用
收藏
页码：741 / 748
页数：8
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