Preneoplastic lesions of the lung

被引：61
作者：
Greenberg, AK [1 ]
Yee, H
Rom, WN
机构：
[1] NYU, Sch Med, Dept Med, Div Pulm & Crit Care Med, New York, NY 10003 USA
[2] NYU, Sch Med, Dept Pathol, New York, NY USA
[3] NYU, Sch Med, Dept Environm Med, New York, NY USA
[4] NYU, Sch Med, Kaplan Canc Ctr, New York, NY USA
来源：
RESPIRATORY RESEARCH | 2002年 / 3卷 / 01期
关键词：
bronchial epithelium; carcinogenesis; lung cancer; preneoplasia;
D O I：
10.1186/rr170
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Lung cancer is the leading cause of cancer deaths worldwide. If we can define and detect preneoplastic lesions, we might have a chance of improving survival. The World Health Organization has defined three preneoplastic lesions of the bronchial epithelium: squamous dysplasia/ carcinoma in situ; atypical adenomatous hyperplasia; and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. These lesions are believed to progress to squamous cell carcinoma, adenocarcinoma and carcinoid tumors, respectively. In this review we summarize the data supporting the preneoplastic nature of these lesions, and delve into some of the genetic changes found in atypical adenomatous hyperplasia and squamous dysplasia/ carcinoma in situ.
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页数：10
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