Synthetic approaches to bridgehead nitrogen methanesulfonamide derivatives of 3-amino-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones, potential COX-2 selective inhibitors

被引：5

作者：

Granata, Giuseppe

Barbagallo, Salvatore

Perdicaro, Antonio

Marrazzo, Agostino

Santagati, Andrea

Lombardo, Laura

Cardile, Venera

机构：

[1] Univ Catania, Dept Pharmaceut Sci, I-95125 Catania, Italy

[2] Univ Catania, Dept Physiol Sci, I-95125 Catania, Italy

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2006年 / 43卷 / 04期

关键词：

D O I：

10.1002/jhet.5570430443

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methane sulfonamide derivatives of 3-amino-2-thioxo-2,3-dihydrothieno [2,3-d] pyimidin-4(1H)-one, potential selective COX-2 inhibitors, were synthesized and their structural elucidation is here reported. Some derivatives, at 10 mu M concentration, showed a significant percentage of inhibition in some in vitro experiments.

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页码：1099 / 1104

页数：6

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